Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 10/20 | 0.50 |
| ▸ | RXRA | P19793 | 7/20 | 0.41 |
| ▸ | RXRB | P28702 | 4/20 | 0.41 |
| ▸ | RXRG | P48443 | 4/20 | 0.41 |
| ▸ | RARB | P10826 | 2/20 | 0.41 |
| ▸ | RARG | P13631 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.41 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.41 |
| ▸ | ESR1 | P03372 | 1/20 | 0.41 |
| ▸ | PGR | P06401 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
| ▸ | RARA | P10276 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | DRD1 | P21728 | 1/20 | 0.41 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3979031 | 0.90 | RXRA (0.55) | HDAC6RXRARXRBRXRGRARB | |
| SCHEMBL13716991 | 0.86 | RXRA (0.44) | HDAC6RXRARXRBRXRGRARB | |
| SCHEMBL13717229 | 0.86 | RXRA (0.45) | HDAC6RXRARXRBRXRGRARB | |
| SCHEMBL13717135 | 0.83 | RXRA (0.40) | HDAC6RXRARXRBRXRGRARB | |
| SCHEMBL13716915 | 0.83 | GSK3A (0.44) | HDAC6RXRARXRBRXRGRARB | |
| SCHEMBL13716944 | 0.82 | PTGS1 (0.45) | HDAC6RXRARXRBRXRGRARB | |
| SCHEMBL13716973 | 0.81 | HDAC1 (0.48) | HDAC6RXRARXRBRXRGRARB | |
| SCHEMBL13745323 | 0.81 | RXRA (0.41) | HDAC6RXRARXRBRXRGRARB | |
| SCHEMBL13717099 | 0.80 | RXRA (0.41) | HDAC6RXRARXRBRXRGRARB | |
| SCHEMBL13717074 | 0.80 | AR (0.43) | HDAC6RXRARXRBRXRGRARB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7572816-B2 | Therapeutic agents for the treatment of cancer, metabolic diseases and skin disorders | AUSPEX PHARMACEUTICALS, INC. (US) | 2009-08-11 | — | — | US | disclosed |
| US-7572816-B2 | Therapeutic agents for the treatment of cancer, metabolic diseases and skin disorders | AUSPEX PHARMACEUTICALS, INC. (US) | 2009-08-11 | — | — | US | disclosed |