Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.41 |
| ▸ | HSP90B1 | P14625 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 3/20 | 0.35 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3979572 | 0.87 | HSP90AA1 (0.41) | HSP90AA1HSP90B1MEN1ALDH1A1CYP1A2 | |
| SCHEMBL3985703 | 0.82 | ALDH1A1 (0.41) | HSP90AA1MEN1ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL3978305 | 0.79 | HSP90AA1 (0.43) | HSP90AA1HSP90B1MEN1KMT2AGRM2 | |
| SCHEMBL3977080 | 0.78 | ALDH1A1 (0.44) | HSP90AA1HSP90B1MEN1ALDH1A1CYP1A2 | |
| SCHEMBL3986843 | 0.78 | HSP90AA1 (0.45) | HSP90AA1HSP90B1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL15497765 | 0.77 | MEN1 (0.49) | HSP90AA1HSP90B1MEN1ALDH1A1CYP1A2 | |
| SCHEMBL13720308 | 0.73 | MAPT (0.45) | HSP90AA1HSP90B1MEN1ALDH1A1CYP1A2 | |
| SCHEMBL3979590 | 0.73 | HSP90AA1 (0.39) | HSP90AA1HSP90B1MAPTRAB9AKCNH2 | |
| SCHEMBL3979725 | 0.72 | HSP90AA1 (0.39) | HSP90AA1HSP90B1MEN1KMT2ARAB9A | |
| Hydrochloric Acid SCHEMBL3979066 | 0.72 | MAPT (0.44) | HSP90AA1HSP90B1MEN1ALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7572921-B2 | Substituted benzylimidazoles useful for the treatment of inflammatory diseases | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-08-11 | — | — | US | disclosed |
| US-7572921-B2 | Substituted benzylimidazoles useful for the treatment of inflammatory diseases | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-08-11 | — | — | US | disclosed |