Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5A | P29375 | 3/20 | 0.41 |
| ▸ | PHF8 | Q9UPP1 | 3/20 | 0.41 |
| ▸ | KDM2A | Q9Y2K7 | 3/20 | 0.41 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.41 |
| ▸ | KDM4A | O75164 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14923374 | 0.86 | EPHX1 (0.42) | KDM5APHF8KDM2AKDM4CKDM4A | |
| SCHEMBL14923304 | 0.83 | KDM5A (0.44) | KDM5APHF8KDM2AKDM4CKDM4A | |
| SCHEMBL12190571 | 0.82 | EPHX1 (0.41) | KDM5APHF8KDM2AKDM4CKDM4A | |
| SCHEMBL12190598 | 0.82 | EPHX1 (0.41) | KDM5APHF8KDM2AKDM4CKDM4A | |
| SCHEMBL14923302 | 0.79 | HPGD (0.39) | KDM5APHF8KDM2AKDM4CKDM4A | |
| SCHEMBL14923346 | 0.79 | HPGD (0.39) | KDM5APHF8KDM2AKDM4CKDM4A | |
| SCHEMBL14923312 | 0.78 | HPGD (0.35) | KDM5APHF8KDM2AKDM4CKDM4A | |
| SCHEMBL17551587 | 0.77 | HPGD (0.34) | KDM5APHF8KDM2AKDM4CKDM4A | |
| SCHEMBL14923297 | 0.76 | KMT2A (0.35) | HPGDALDH1A1MEN1KMT2AEPHX1 | |
| SCHEMBL17715603 | 0.76 | HPGD (0.41) | KDM5APHF8KDM2AKDM4CKDM4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1838304-B1 | HETEROCYCLIC ASPARTYL PROTEASE INHIBITORS | SCHERING CORP (US) | 2009-08-19 | — | — | EP | disclosed |