Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14923374 | 0.86 | EPHX1 (0.42) | KMT2AMEN1NPC1RAB9AHPGD | |
| SCHEMBL14923304 | 0.79 | KDM5A (0.44) | KMT2ANPC1RAB9AHPGDEPHX1 | |
| SCHEMBL14923312 | 0.79 | HPGD (0.35) | KMT2AMEN1NPC1RAB9AHPGD | |
| SCHEMBL17551587 | 0.78 | HPGD (0.34) | KMT2AMEN1NPC1RAB9AHPGD | |
| SCHEMBL14923346 | 0.77 | HPGD (0.39) | KMT2AMEN1NPC1RAB9AHPGD | |
| SCHEMBL14923302 | 0.77 | HPGD (0.39) | KMT2AMEN1NPC1RAB9AHPGD | |
| SCHEMBL13722304 | 0.76 | KDM5A (0.41) | KMT2AMEN1NPC1RAB9AHPGD | |
| SCHEMBL14923325 | 0.76 | HPGD (0.36) | KMT2AMEN1NPC1RAB9AHPGD | |
| SCHEMBL17715619 | 0.75 | CTSD (0.38) | KMT2AMEN1NPC1RAB9AHPGD | |
| SCHEMBL14923322 | 0.74 | KMT2A (0.40) | KMT2AMEN1NPC1RAB9AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1699455-B1 | HETEROCYCLIC ASPARTYL PROTEASE INHIBITORS | MERCK SHARP & DOHME (US) | 2013-05-08 | — | — | EP | disclosed |