Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP1 | P53582 | 1/20 | 0.58 |
| ▸ | METAP2 | P50579 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3719547 | 0.83 | METAP2 (0.50) | METAP1METAP2SIGMAR1CYP1A2 | |
| SCHEMBL7852214 | 0.83 | METAP2 (0.50) | METAP1METAP2SIGMAR1CYP1A2 | |
| SCHEMBL3719549 | 0.83 | METAP2 (0.50) | METAP1METAP2SIGMAR1CYP1A2 | |
| SCHEMBL12321606 | 0.82 | METAP1 (0.57) | METAP1METAP2SIGMAR1CYP1A2TP53 | |
| SCHEMBL16306469 | 0.82 | METAP1 (0.57) | METAP1METAP2SIGMAR1CYP1A2TP53 | |
| SCHEMBL6934478 | 0.82 | METAP1 (0.57) | METAP1METAP2SIGMAR1CYP1A2TP53 | |
| Hydrochloric Acid SCHEMBL4430187 | 0.80 | METAP1 (0.55) | METAP1METAP2SIGMAR1CYP1A2TP53 | |
| SCHEMBL7334866 | 0.79 | METAP1 (0.50) | METAP1METAP2SIGMAR1CYP1A2TP53 | |
| SCHEMBL17613550 | 0.78 | METAP1 (0.48) | METAP1METAP2SIGMAR1CYP1A2 | |
| SCHEMBL10727830 | 0.78 | METAP1 (0.49) | METAP1METAP2SIGMAR1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1838304-B1 | HETEROCYCLIC ASPARTYL PROTEASE INHIBITORS | SCHERING CORP (US) | 2009-08-19 | — | — | EP | disclosed |