Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 18/20 | 0.69 |
| ▸ | JAK3 | P52333 | 9/20 | 0.65 |
| ▸ | JAK1 | P23458 | 5/20 | 0.65 |
| ▸ | TYK2 | P29597 | 4/20 | 0.65 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.60 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.60 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.59 |
| ▸ | NCOR1 | O75376 | 1/20 | 0.59 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.59 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.59 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.59 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13725012 | 0.91 | JAK2 (0.67) | JAK2JAK3JAK1TYK2MAPK8 | |
| SCHEMBL3622937 | 0.87 | JAK2 (0.80) | JAK2JAK3JAK1TYK2MAPK8 | |
| SCHEMBL13253257 | 0.86 | JAK2 (0.68) | JAK2JAK3JAK1TYK2MAPK8 | |
| SCHEMBL13725016 | 0.85 | JAK2 (0.72) | JAK2JAK3JAK1TYK2MAPK8 | |
| SCHEMBL5479846 | 0.83 | PLK1 (0.66) | JAK2JAK3MAPK8MAPK10 | |
| SCHEMBL4734676 | 0.83 | JAK2 (0.71) | JAK2JAK3JAK1TYK2MAPK8 | |
| SCHEMBL12801112 | 0.82 | JAK2 (1.00) | JAK2JAK3JAK1TYK2MAPK8 | |
| SCHEMBL2870956 | 0.82 | JAK2 (0.78) | JAK2JAK3JAK1TYK2MAPK8 | |
| SCHEMBL4379023 | 0.81 | JAK2 (0.80) | JAK2JAK3JAK1TYK2MAPK8 | |
| SCHEMBL4381946 | 0.81 | JAK2 (0.76) | JAK2JAK3JAK1TYK2MAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2704722-A1 | MULTIPLE MYELOMA TREATMENT | YM BioSciences Australia Pty Ltd (US) | 2014-03-12 | — | — | EP | disclosed |
| WO-2012149602-A1 | MULTIPLE MYELOMA TREATMENT | YM BIOSCIENCES AUSTRALIA PTY LTD (AU) | 2012-11-08 | — | — | WO | disclosed |