Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.60 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.54 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.54 |
| ▸ | DRD4 | P21917 | 3/20 | 0.52 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | BCHE | P06276 | 1/20 | 0.49 |
| ▸ | ACHE | P22303 | 1/20 | 0.49 |
| ▸ | BACE1 | P56817 | 1/20 | 0.49 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL82814 | 1.00 | HPGD (0.60) | HPGDHRH3HRH4DRD4TMEM97 | |
| SCHEMBL13215734 | 0.90 | HRH3 (0.61) | HPGDHRH3HRH4ALDH1A1LMNA | |
| SCHEMBL13727089 | 0.90 | HRH3 (0.61) | HPGDHRH3HRH4ALDH1A1LMNA | |
| SCHEMBL19107773 | 0.90 | HRH3 (0.61) | HPGDHRH3HRH4ALDH1A1LMNA | |
| SCHEMBL13727922 | 0.87 | GAA (0.58) | HRH3HRH4ALDH1A1 | |
| SCHEMBL16254956 | 0.87 | GAA (0.58) | HRH3HRH4ALDH1A1 | |
| SCHEMBL8244556 | 0.87 | HRH3 (0.54) | HPGDHRH3HRH4ALDH1A1LMNA | |
| SCHEMBL19851034 | 0.85 | ALDH1A1 (0.56) | HPGDHRH3HRH4ALDH1A1POLB | |
| SCHEMBL6189062 | 0.85 | ALDH1A1 (0.59) | HPGDHRH3HRH4ALDH1A1LMNA | |
| SCHEMBL12717 | 0.85 | CYP3A4 (0.66) | HPGDHRH3HRH4SIGMAR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090203663-A1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2009-08-13 | — | — | US | disclosed |
| US-20090203663-A1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2009-08-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090203663-A1 | CHEMICAL COMPOUNDS | ITGB5, ITGB1, ITGA2B | HPGD 2035/4885HRH3 2121/4885HRH4 2369/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.