Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.71 |
| ▸ | MAPT | P10636 | 1/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.60 |
| ▸ | MEN1 | O00255 | 3/20 | 0.60 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 11/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.56 |
| ▸ | NPC1 | O15118 | 4/20 | 0.56 |
| ▸ | RAB9A | P51151 | 3/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | ATM | Q13315 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | NAMPT | P43490 | 2/20 | 0.51 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3675630 | 0.83 | POLB (1.00) | POLBMAPTKMT2AMEN1HTT | |
| SCHEMBL30880779 | 0.81 | POLB (0.69) | POLBMAPTKMT2AMEN1HTT | |
| SCHEMBL13210604 | 0.80 | KMT2A (0.72) | POLBMAPTKMT2AMEN1HTT | |
| SCHEMBL23553433 | 0.80 | POLB (0.67) | POLBMAPTKMT2AMEN1HTT | |
| SCHEMBL30880768 | 0.77 | POLB (0.64) | POLBMAPTKMT2AMEN1HTT | |
| SCHEMBL19372277 | 0.76 | KMT2A (0.59) | POLBMAPTKMT2AMEN1HTT | |
| SCHEMBL13162046 | 0.76 | KMT2A (0.59) | POLBMAPTKMT2AMEN1HPGD | |
| SCHEMBL13162030 | 0.76 | KMT2A (0.59) | POLBMAPTKMT2AMEN1HPGD | |
| SCHEMBL3668332 | 0.76 | POLB (0.87) | POLBMAPTKMT2AMEN1HTT | |
| SCHEMBL7456339 | 0.75 | MEN1 (0.58) | POLBMAPTKMT2AMEN1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012151567-A1 | PYRIMIDINONE COMPOUNDS AND METHODS FOR PREVENTING AND TREATING INFLUENZA | ST. JUDE CHILDREN'S RESEARCH HOSPITAL (US) | 2012-11-08 | — | — | WO | disclosed |