Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.69 |
| ▸ | MAPT | P10636 | 1/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 7/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.52 |
| ▸ | NAMPT | P43490 | 2/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.51 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30880768 | 0.96 | POLB (0.64) | POLBMAPTKMT2AMEN1HTT | |
| SCHEMBL21722478 | 0.93 | POLB (0.59) | POLBMAPTKMT2AMEN1HTT | |
| SCHEMBL30880764 | 0.93 | POLB (0.59) | POLBMAPTKMT2AMEN1HTT | |
| SCHEMBL22640162 | 0.83 | HDAC1 (0.57) | POLBMAPTKMT2AMEN1HTT | |
| SCHEMBL22640177 | 0.83 | HDAC1 (0.57) | POLBMAPTKMT2AMEN1HTT | |
| SCHEMBL3675630 | 0.82 | POLB (1.00) | POLBMAPTKMT2AMEN1HTT | |
| SCHEMBL13729596 | 0.81 | POLB (0.71) | POLBMAPTKMT2AMEN1HTT | |
| SCHEMBL30880761 | 0.80 | LMNA (0.52) | POLBMAPTKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL30880731 | 0.78 | NAMPT (0.50) | MAPTKMT2AMEN1HPGDSMN1; SMN2 | |
| SCHEMBL23553433 | 0.78 | POLB (0.67) | POLBMAPTKMT2AMEN1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115181092-B | Pyrazine compounds and uses thereof | 迪哲(江苏)医药股份有限公司 | 2024-05-03 | — | — | CN | disclosed |