Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | CTSK | P43235 | 5/20 | 0.38 |
| ▸ | CTSS | P25774 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA7 | P43166 | 1/20 | 0.36 |
| ▸ | CTSL | P07711 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13729938 | 1.00 | SMN1; SMN2 (0.43) | SMN1; SMN2CTSKCTSSCYP1A2CYP2C9 | |
| SCHEMBL17371049 | 0.90 | SMN1; SMN2 (0.41) | SMN1; SMN2CTSKCTSSCYP1A2CYP2C9 | |
| SCHEMBL13728227 | 0.88 | CTSK (0.42) | SMN1; SMN2CTSKCTSSCA1CA2 | |
| SCHEMBL13729111 | 0.88 | CTSK (0.42) | SMN1; SMN2CTSKCTSSCA1CA2 | |
| SCHEMBL13830117 | 0.88 | SMN1; SMN2 (0.44) | SMN1; SMN2CTSKCTSSCYP1A2CYP2C9 | |
| SCHEMBL19481573 | 0.83 | SMN1; SMN2 (0.43) | SMN1; SMN2CTSKCTSSCYP1A2CYP2C9 | |
| SCHEMBL14317721 | 0.78 | SMN1; SMN2 (0.45) | SMN1; SMN2CTSKCTSSCYP1A2CYP2C9 | |
| SCHEMBL16011870 | 0.77 | CTSK (0.38) | CTSKCTSSHTTCA1CA2 | |
| SCHEMBL16011869 | 0.77 | CTSK (0.38) | CTSKCTSSHTTCA1CA2 | |
| SCHEMBL13728351 | 0.77 | CTSK (0.41) | CTSKCTSSCA1CA2CA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2914598-B1 | HEPATITIS C VIRUS INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2017-10-18 | — | — | EP | disclosed |
| EP-2705049-A1 | HEPATITIS C VIRUS INHIBITORS | Bristol-Myers Squibb Company (US) | 2014-03-12 | — | — | EP | disclosed |
| WO-2012151195-A1 | HEPATITIS C VIRUS INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-11-08 | — | — | WO | disclosed |