SCHEMBL1372995

SCHEMBL1372995

O=C1C=C(OC(=O)c2cc3cccnc3n(Cc3ccccc3)c2=O)CCC1

nearest known ligand 0.57

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
CNR1 P21554 13/20 0.57
CNR2 P34972 11/20 0.57
MEN1 O00255 2/20 0.43
KMT2A Q03164 2/20 0.43
KDM4E B2RXH2 1/20 0.43
CYP1A2 P05177 1/20 0.43
CYP3A4 P08684 1/20 0.43
CYP2D6 P10635 1/20 0.43
CYP2C19 P33261 1/20 0.43
ATM Q13315 1/20 0.43
PDE4A P27815 1/20 0.39
PDE4B Q07343 1/20 0.39
PDE4C Q08493 1/20 0.39
PDE4D Q08499 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1372638 0.86 MAPT (0.46) CNR1CNR2
SCHEMBL1372778 0.84 MET (0.44) CNR1CNR2PDE4B
SCHEMBL1373864 0.84 CNR2 (0.42) CNR1CNR2
SCHEMBL1373120 0.82 AHR (0.51) CNR1CNR2
SCHEMBL1372681 0.79 CNR1 (0.66) CNR1CNR2MEN1KMT2AKDM4E
SCHEMBL1374001 0.79 CNR1 (0.59) CNR1CNR2MEN1KMT2AKDM4E
SCHEMBL1373635 0.78 CNR1 (0.65) CNR1CNR2MEN1KMT2AKDM4E
Hydrochloric Acid SCHEMBL1373638 0.78 CNR1 (0.65) CNR1CNR2MEN1KMT2AKDM4E
SCHEMBL1372691 0.77 CNR2 (0.59) CNR1CNR2MEN1KMT2AKDM4E
SCHEMBL1374850 0.75 MET (0.37) PDE4BPDE4D

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2394995-B1 RING-FUSED 2-PYRIDONE DERIVATIVES AND HERBICIDES KUMIAI CHEMICAL INDUSTRY CO (JP) 2014-01-15 EP disclosed
US-8334236-B2 Ring-fused 2-pyridone derivatives and herbicides KUMIAI CHEMICAL INDUSTRY CO., LTD. (JP) 2012-12-18 US disclosed
EP-2394995-A1 RING-FUSED 2-PYRIDONE DERIVATIVES AND HERBICIDES Kumiai Chemical Industry CO., LTD. (JP) 2011-12-14 EP disclosed
US-20110287937-A1 RING-FUSED 2-PYRIDONE DERIVATIVES AND HERBICIDES IHARA CHEMICAL INDUSTRY CO., LTD. (JP) 2011-11-24 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110287937-A1 RING-FUSED 2-PYRIDONE DERIVATIVES AND HERBICIDES CBR3, CBR1, CHRM1 CNR1 327/4885CNR2 516/4885MEN1 4177/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.