Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 6/20 | 0.42 |
| ▸ | IDO1 | P14902 | 2/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | HPGDS | O60760 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 4/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.34 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.34 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16389085 | 0.87 | NOTUM (0.41) | NOTUMIDO1PIM1HPGDSPOLB | |
| SCHEMBL1812515 | 0.77 | IDO1 (0.40) | NOTUMIDO1PIM1HPGDSPOLB | |
| SCHEMBL1810095 | 0.75 | NOTUM (0.51) | NOTUMIDO1PIM1HPGDSPOLB | |
| SCHEMBL1814795 | 0.75 | NOTUM (0.59) | NOTUMIDO1HPGDSPOLBPTPN11 | |
| Hydrochloric Acid SCHEMBL13733073 | 0.74 | NOTUM (0.50) | NOTUMIDO1PIM1HPGDSPOLB | |
| SCHEMBL29176712 | 0.72 | HPGDS (0.50) | NOTUMIDO1PIM1HPGDSPOLB | |
| SCHEMBL30970763 | 0.70 | HPGDS (0.50) | NOTUMIDO1PIM1HPGDSPOLB | |
| SCHEMBL1820599 | 0.69 | NOTUM (0.59) | NOTUMPIM1HPGDSPOLBPTPN11 | |
| Hydrochloric Acid SCHEMBL1817306 | 0.68 | NOTUM (0.57) | NOTUMPIM1HPGDSPOLBPTPN11 | |
| SCHEMBL30970730 | 0.67 | PIM1 (0.61) | NOTUMIDO1PIM1HPGDSPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2699561-B1 | ANDROGEN RECEPTOR MODULATING CARBOXAMIDES | ORION CORP (FI) | 2015-06-03 | — | — | EP | disclosed |
| US-8921378-B2 | Androgen receptor modulating carboxamides | ORION CORPORATION (FI) | 2014-12-30 | — | — | US | disclosed |
| EP-2699561-A1 | ANDROGEN RECEPTOR MODULATING CARBOXAMIDES | Orion Corporation (FI) | 2014-02-26 | — | — | EP | disclosed |
| WO-2012143599-A1 | ANDROGEN RECEPTOR MODULATING CARBOXAMIDES | ORION CORPORATION (FI) | 2012-10-26 | — | — | WO | disclosed |