Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 3/20 | 0.66 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.53 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.51 |
| ▸ | DHODH | Q02127 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.49 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | AHR | P35869 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | STAT6 | P42226 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28692378 | 0.87 | DHODH (0.61) | SYKDHODHCYP1A2CYP3A4HSD17B10 | |
| SCHEMBL30240907 | 0.85 | RAB9A (0.63) | SYKZAP70MAPK8MAPTNPC1 | |
| SCHEMBL30085364 | 0.83 | SYK (0.68) | SYKZAP70STAT6AURKB | |
| SCHEMBL28787832 | 0.83 | SYK (0.68) | SYKEGFRAURKARPS6KB1LMNA | |
| SCHEMBL16782419 | 0.83 | SYK (0.68) | SYKZAP70STAT6AURKB | |
| SCHEMBL28685508 | 0.82 | CYP1A2 (0.53) | SYKDHODHCYP1A2CYP3A4HSD17B10 | |
| SCHEMBL30240978 | 0.80 | SYK (0.57) | SYKCYP1A2CYP3A4HSD17B10ALDH1A1 | |
| SCHEMBL3712006 | 0.78 | RPS6KB1 (0.63) | CYP1A2CYP3A4HSD17B10ALDH1A1ALOX15 | |
| SCHEMBL479805 | 0.78 | DHODH (0.76) | DHODHHSD17B10ALDH1A1MAPTNPC1 | |
| SCHEMBL31629762 | 0.76 | DHODH (0.55) | SYKDHODHCYP1A2CYP3A4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2699553-A1 | SUBSTITUTED DIAMINOCARBOXAMIDE AND DIAMINOCARBONITRILE PYRIMIDINES, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH | Signal Pharmaceuticals, LLC (US) | 2014-02-26 | — | — | EP | disclosed |
| WO-2012145569-A1 | SUBSTITUTED DIAMINOCARBOXAMIDE AND DIAMINOCARBONITRILE PYRIMIDINES, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH | SIGNAL PHARMACEUTICALS, LLC (US) | 2012-10-26 | — | — | WO | disclosed |