Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 6/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | QDPR | P09417 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15523084 | 1.00 | EPHX2 (0.40) | EPHX2EPHX1CYP1A2TDP1KDM4E | |
| SCHEMBL27636829 | 0.84 | HDAC8 (0.36) | HDAC8 | |
| SCHEMBL24434580 | 0.80 | EPHX2 (0.42) | EPHX2EPHX1CYP1A2TDP1KDM4E | |
| SCHEMBL14317303 | 0.80 | EPHX2 (0.42) | EPHX2EPHX1CYP1A2TDP1KDM4E | |
| SCHEMBL2666145 | 0.78 | EPHX2 (0.53) | EPHX2EPHX1CYP1A2TDP1KDM4E | |
| SCHEMBL1722011 | 0.76 | HPGD (0.50) | EPHX1KDM4ESMN1; SMN2 | |
| SCHEMBL21041256 | 0.76 | GAA (0.41) | TDP1SMN1; SMN2 | |
| SCHEMBL1722010 | 0.76 | HPGD (0.50) | EPHX1KDM4ESMN1; SMN2 | |
| SCHEMBL892513 | 0.76 | TSHR (0.44) | TDP1SMN1; SMN2HDAC8 | |
| SCHEMBL821436 | 0.76 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11572368-B2 | Inhibitors of histone deacetylase | THE GENERAL HOSPITAL CORPORATION (US) | 2023-02-07 | — | — | US | disclosed |
| US-11485725-B2 | Derivatives of piperlongumine and uses thereof | AURANSA INC. (US) | 2022-11-01 | — | — | US | disclosed |
| US-20210198235-A1 | DERIVATIVES OF PIPERLONGUMINE AND USES THEREOF | AURANSA INC. | 2021-07-01 | — | — | US | disclosed |
| US-20210198235-A1 | DERIVATIVES OF PIPERLONGUMINE AND USES THEREOF | AURANSA INC. | 2021-07-01 | — | — | US | disclosed |
| US-20200377510-A1 | DERIVATIVES OF PIPERLONGUMINE AND USES THEREOF | AURANSA INC. | 2020-12-03 | — | — | US | disclosed |
| US-20200377510-A1 | DERIVATIVES OF PIPERLONGUMINE AND USES THEREOF | AURANSA INC. | 2020-12-03 | — | — | US | disclosed |
| US-10662199-B2 | Inhibitors of histone deacetylase | THE BROAD INSTITUTE, INC. (US) | 2020-05-26 | — | — | US | disclosed |
| EP-2701699-B1 | INHIBITORS OF HISTONE DEACETYLASE | BROAD INST INC (US) | 2019-10-16 | — | — | EP | disclosed |
| WO-2019103897-A1 | DERIVATIVES OF PIPERLONGUMINE AND USES THEREOF | AURANSA INC. (US) | 2019-05-31 | — | — | WO | disclosed |
| WO-2019103897-A1 | DERIVATIVES OF PIPERLONGUMINE AND USES THEREOF | AURANSA INC. (US) | 2019-05-31 | — | — | WO | disclosed |
| US-20180016282-A9 | INHIBITORS OF HISTONE DEACETYLASE | HOWARD HUGHES MEDICAL INSTITUTE | 2018-01-18 | — | — | US | disclosed |
| US-20170217955-A9 | INHIBITORS OF HISTONE DEACETYLASE | THE BROAD INSTITUTE, INC. (US) | 2017-08-03 | — | — | US | disclosed |
| US-20160347761-A1 | INHIBITORS OF HISTONE DEACETYLASE | THE GENERAL HOSPITAL CORP D/B/A MASSACHUSETTS GENERAL HOSPITAL (US) | 2016-12-01 | — | — | US | disclosed |
| US-9447030-B2 | Inhibitors of histone deacetylase | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2016-09-20 | — | — | US | disclosed |
| US-20160251351-A1 | INHIBITORS OF HISTONE DEACETYLASE | THE BROAD INSTITUTE, INC. (US) | 2016-09-01 | — | — | US | disclosed |
| US-9365498-B2 | Inhibitors of histone deacetylase | THE BROAD INSTITUTE, INC. (US) | 2016-06-14 | — | — | US | disclosed |
| US-20140080802-A1 | Inhibitors of Histone Deacetylase | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 2014-03-20 | — | — | US | disclosed |
| US-20140080800-A1 | Inhibitors of Histone Deacetylase | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 2014-03-20 | — | — | US | disclosed |
| EP-2701699-A1 | INHIBITORS OF HISTONE DEACETYLASE | The Broad Institute, Inc. (US) | 2014-03-05 | — | — | EP | disclosed |
| WO-2012149540-A1 | INHIBITORS OF HISTONE DEACETYLASE | THE BROAD INSTITUTE INC (US) | 2012-11-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140080800-A1 | Inhibitors of Histone Deacetylase | HDAC2, HDAC1, HDAC11 | EPHX2 2012/4885EPHX1 1746/4885CYP1A2 2050/4885 |
| US-20200377510-A1 | DERIVATIVES OF PIPERLONGUMINE AND USES THEREOF | SHARPIN, PIR, THPO | EPHX2 2593/4885EPHX1 2418/4885CYP1A2 1034/4885 |
| US-20160347761-A1 | INHIBITORS OF HISTONE DEACETYLASE | HDAC2, HDAC1, HDAC11 | EPHX2 2012/4885EPHX1 1746/4885CYP1A2 2050/4885 |
| US-10662199-B2 | Inhibitors of histone deacetylase | HDAC2, HDAC1, HDAC11 | EPHX2 2012/4885EPHX1 1746/4885CYP1A2 2050/4885 |
| US-11572368-B2 | Inhibitors of histone deacetylase | HDAC2, HDAC1, HDAC11 | EPHX2 2012/4885EPHX1 1746/4885CYP1A2 2050/4885 |
| US-20160251351-A1 | INHIBITORS OF HISTONE DEACETYLASE | HDAC1, HDAC2, HDAC11 | EPHX2 2571/4885EPHX1 1812/4885CYP1A2 2111/4885 |
| US-20140080802-A1 | Inhibitors of Histone Deacetylase | HDAC2, HDAC1, HDAC11 | EPHX2 2012/4885EPHX1 1746/4885CYP1A2 2050/4885 |
| US-20170217955-A9 | INHIBITORS OF HISTONE DEACETYLASE | HDAC1, HDAC2, HDAC11 | EPHX2 2571/4885EPHX1 1812/4885CYP1A2 2111/4885 |
| US-20210198235-A1 | DERIVATIVES OF PIPERLONGUMINE AND USES THEREOF | THPO, PIR, PAK6 | EPHX2 2401/4885EPHX1 2324/4885CYP1A2 417/4885 |
| US-20180016282-A9 | INHIBITORS OF HISTONE DEACETYLASE | HDAC2, HDAC1, HDAC11 | EPHX2 2012/4885EPHX1 1746/4885CYP1A2 2050/4885 |
| US-11485725-B2 | Derivatives of piperlongumine and uses thereof | PIR, THPO, DHPS | EPHX2 2463/4885EPHX1 2273/4885CYP1A2 380/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.