Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | HTT | P42858 | 2/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3225661 | 1.00 | MAPT (0.35) | MAPTALDH1A1LMNAMAPK1SMN1; SMN2 | |
| SCHEMBL3225648 | 1.00 | MAPT (0.35) | MAPTALDH1A1LMNAMAPK1SMN1; SMN2 | |
| SCHEMBL3225672 | 1.00 | MAPT (0.35) | MAPTALDH1A1LMNAMAPK1SMN1; SMN2 | |
| SCHEMBL18430028 | 0.91 | MAPT (0.34) | MAPTALDH1A1LMNAMAPK1SMN1; SMN2 | |
| SCHEMBL13421932 | 0.91 | MAPT (0.34) | MAPTALDH1A1LMNAMAPK1SMN1; SMN2 | |
| SCHEMBL16505472 | 0.90 | MAPT (0.33) | MAPTALDH1A1LMNAMAPK1SMN1; SMN2 | |
| SCHEMBL16505471 | 0.90 | MAPT (0.33) | MAPTALDH1A1LMNAMAPK1SMN1; SMN2 | |
| SCHEMBL16505469 | 0.90 | MAPT (0.33) | MAPTALDH1A1LMNAMAPK1SMN1; SMN2 | |
| SCHEMBL17420347 | 0.90 | MAPT (0.33) | MAPTALDH1A1LMNAMAPK1SMN1; SMN2 | |
| SCHEMBL17420350 | 0.90 | MAPT (0.33) | MAPTALDH1A1LMNAMAPK1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2702063-A1 | BICYCLIC PYRIDAZINE COMPOUNDS AS PIM INHIBITORS | Amgen Inc. (US) | 2014-03-05 | — | — | EP | disclosed |
| WO-2012148775-A1 | BICYCLIC PYRIDAZINE COMPOUNDS AS PIM INHIBITORS | AMGEN INC. (US) | 2012-11-01 | — | — | WO | disclosed |