Sugi Predict

Sugi Predict / Compounds / SCHEMBL3225672

SCHEMBL3225672

SCHEMBL3225672

C[C@H]1CN(c2ccncc2[N+](=O)[O-])C[C@@H](NC(=O)O)[C@@H]1O[Si](C)(C)C(C)(C)C

nearest known ligand 0.35

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
▸ MAPT P10636 6/20 0.35
▸ ALDH1A1 P00352 2/20 0.35
▸ LMNA P02545 1/20 0.32
▸ MAPK1 P28482 1/20 0.32
▸ SMN1; SMN2 Q16637 1/20 0.32
▸ KMT2A Q03164 2/20 0.31
▸ HTT P42858 2/20 0.31
▸ POLB P06746 1/20 0.31
▸ MEN1 O00255 1/20 0.30
▸ PIM2 Q9P1W9 2/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3225661 1.00 MAPT (0.35) MAPTALDH1A1LMNAMAPK1SMN1; SMN2
SCHEMBL3225648 1.00 MAPT (0.35) MAPTALDH1A1LMNAMAPK1SMN1; SMN2
SCHEMBL13735652 1.00 MAPT (0.35) MAPTALDH1A1LMNAMAPK1SMN1; SMN2
SCHEMBL18430028 0.91 MAPT (0.34) MAPTALDH1A1LMNAMAPK1SMN1; SMN2
SCHEMBL13421932 0.91 MAPT (0.34) MAPTALDH1A1LMNAMAPK1SMN1; SMN2
SCHEMBL16505472 0.90 MAPT (0.33) MAPTALDH1A1LMNAMAPK1SMN1; SMN2
SCHEMBL16505471 0.90 MAPT (0.33) MAPTALDH1A1LMNAMAPK1SMN1; SMN2
SCHEMBL16505469 0.90 MAPT (0.33) MAPTALDH1A1LMNAMAPK1SMN1; SMN2
SCHEMBL17420347 0.90 MAPT (0.33) MAPTALDH1A1LMNAMAPK1SMN1; SMN2
SCHEMBL17420350 0.90 MAPT (0.33) MAPTALDH1A1LMNAMAPK1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 41 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023211256-A1 NOVEL PIM KINASE INHIBITORS AND USES THEREOF 제일약품주식회사 2023-11-02 — — WO disclosed
US-10000507-B2 Furo- and thieno-pyridine carboxamide compounds useful as pim kinase inhibitors INCYTE CORPORATION (US) 2018-06-19 — — US disclosed
US-9890162-B2 Bicyclic aromatic carboxamide compounds useful as pim kinase inhibitors INCYTE CORPORATION (US) 2018-02-13 — — US disclosed
US-9822124-B2 Bicyclic heteroaromatic carboxamide compounds useful as Pim kinase inhibitors INCYTE CORPORATION (US) 2017-11-21 — — US disclosed
US-9802918-B2 Pyridineamine compounds useful as Pim kinase inhibitors INCYTE CORPORATION (US) 2017-10-31 — — US disclosed
EP-2943485-B1 BICYCLIC AROMATIC CARBOXAMIDE COMPOUNDS USEFUL AS PIM KINASE INHIBITORS INCYTE HOLDINGS CORP (US) 2017-09-20 — — EP disclosed
US-20170253587-A1 BICYCLIC AROMATIC CARBOXAMIDE COMPOUNDS USEFUL AS PIM KINASE INHIBITORS INCYTE CORPORATION 2017-09-07 — — US disclosed
US-20170190716-A1 FURO- AND THIENO-PYRIDINE CARBOXAMIDE COMPOUNDS USEFUL AS PIM KINASE INHIBITORS INCYTE CORPORATION 2017-07-06 — — US disclosed
US-9676750-B2 Bicyclic aromatic carboxamide compounds useful as pim kinase inhibitors INCYTE CORPORATION (US) 2017-06-13 — — US disclosed
US-20170158670-A1 PYRIDINEAMINE COMPOUNDS USEFUL AS PIM KINASE INHIBITORS INCYTE CORPORATION 2017-06-08 — — US disclosed
EP-2702063-A1 BICYCLIC PYRIDAZINE COMPOUNDS AS PIM INHIBITORS Amgen Inc. (US) 2014-03-05 — — EP disclosed
EP-2681195-A1 NOVEL KINASE INHIBITORS Novartis AG (CH) 2014-01-08 — — EP disclosed
US-20130336965-A1 NOVEL RING-SUBSTITUTED N-PYRIDINYL AMIDES AS KINASE INHIBITORS NOVARTIS AG (CH) 2013-12-19 — — US disclosed
US-8592455-B2 Kinase inhibitors and methods of their use NOVARTIS AG (CH) 2013-11-26 — — US disclosed
US-8329732-B2 Kinase inhibitors and methods of their use NOVARTIS AG (CH) 2012-12-11 — — US disclosed
WO-2012148775-A1 BICYCLIC PYRIDAZINE COMPOUNDS AS PIM INHIBITORS AMGEN INC. (US) 2012-11-01 — — WO disclosed
WO-2012120428-A1 NOVEL KINASE INHIBITORS NOVARTIS AG (CH) 2012-09-13 — — WO disclosed
US-20120225062-A1 NOVEL KINASE INHIBITORS NOVARTIS VACCINES AND DIAGNOSTICS, INC. 2012-09-06 — — US disclosed
US-20120134987-A1 KINASE INHIBITORS AND METHODS OF THEIR USE BURGER MATTHEW T (US) 2012-05-31 — — US disclosed
US-20100056576-A1 Kinase inhibitors and methods of their use NOVARTIS AG (CH) 2010-03-04 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170190716-A1 FURO- AND THIENO-PYRIDINE CARBOXAMIDE COMPOUNDS USEFUL AS PIM KINASE INHIBITORS PIM1, PIM2, PIM3 MAPT 2941/4885ALDH1A1 2130/4885LMNA 3590/4885
US-20130336965-A1 NOVEL RING-SUBSTITUTED N-PYRIDINYL AMIDES AS KINASE INHIBITORS PIM1, PIM2, MAP3K1 MAPT 384/4885ALDH1A1 1348/4885LMNA 1769/4885
US-20120134987-A1 KINASE INHIBITORS AND METHODS OF THEIR USE PIM1, PIM2, PIM3 MAPT 3029/4885ALDH1A1 2467/4885LMNA 2729/4885
US-20100056576-A1 Kinase inhibitors and methods of their use PIM1, PIM2, PIM3 MAPT 3029/4885ALDH1A1 2467/4885LMNA 2729/4885
US-20120225062-A1 NOVEL KINASE INHIBITORS PIM1, PIM2, PIM3 MAPT 3688/4885ALDH1A1 1758/4885LMNA 3033/4885
US-10000507-B2 Furo- and thieno-pyridine carboxamide compounds useful as pim kinase inhibitors PIM1, PIM2, PIM3 MAPT 2941/4885ALDH1A1 2130/4885LMNA 3590/4885
US-20170253587-A1 BICYCLIC AROMATIC CARBOXAMIDE COMPOUNDS USEFUL AS PIM KINASE INHIBITORS PIM1, PIM2, PIM3 MAPT 3113/4885ALDH1A1 2531/4885LMNA 2130/4885
US-20170158670-A1 PYRIDINEAMINE COMPOUNDS USEFUL AS PIM KINASE INHIBITORS PIM1, PIM2, PIM3 MAPT 3095/4885ALDH1A1 2555/4885LMNA 2135/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.