Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 16/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13739018 | 0.83 | GRM5 (0.59) | GRM5CYP2C19 | |
| SCHEMBL20212775 | 0.71 | HSD11B1 (0.41) | GRM5ALDH1A1CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL2708314 | 0.71 | HSD11B1 (0.41) | GRM5ALDH1A1CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL20212776 | 0.71 | HSD11B1 (0.41) | GRM5ALDH1A1CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL13739350 | 0.71 | GRM5 (0.74) | GRM5 | |
| SCHEMBL20212746 | 0.70 | GRM5 (0.31) | GRM5 | |
| SCHEMBL20212747 | 0.70 | GRM5 (0.31) | GRM5 | |
| SCHEMBL20212777 | 0.70 | GRM5 (0.31) | GRM5 | |
| SCHEMBL22032235 | 0.70 | GRM5 (0.31) | GRM5 | |
| SCHEMBL13737758 | 0.70 | GRM5 (0.64) | GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012152854-A1 | METABOTROPIC GLUTAMATE RECEPTOR MODULATORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2012-11-15 | — | — | WO | disclosed |