Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | KIF11 | P52732 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | AKT1 | P31749 | 1/20 | 0.44 |
| ▸ | AKT2 | P31751 | 1/20 | 0.44 |
| ▸ | DPP4 | P27487 | 1/20 | 0.43 |
| ▸ | BACE1 | P56817 | 1/20 | 0.43 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.43 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | TOP1 | P11387 | 1/20 | 0.42 |
| ▸ | CFTR | P13569 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13737492 | 0.86 | MAPT (0.57) | KDM4EALDH1A1MAPTSMN1; SMN2GAA | |
| SCHEMBL13736647 | 0.86 | RECQL (0.51) | KDM4EALDH1A1MAPTNR1H2NR1H3 | |
| SCHEMBL13738455 | 0.83 | MAPT (0.45) | MAPTNR1H2NR1H3MEN1KMT2A | |
| SCHEMBL13738541 | 0.81 | TDP1 (0.51) | KDM4EALDH1A1MAPTNR1H2NR1H3 | |
| SCHEMBL13066524 | 0.80 | MEN1 (0.46) | KIF11NR1H2NR1H3MEN1KMT2A | |
| SCHEMBL13736982 | 0.80 | RECQL (0.44) | KDM4EALDH1A1MAPTNR1H2NR1H3 | |
| SCHEMBL13826372 | 0.79 | KDM4E (0.43) | KDM4EALDH1A1KIF11MAPTBACE1 | |
| SCHEMBL13430367 | 0.78 | POLB (0.54) | KDM4EALDH1A1NR1H2NR1H3NPC1 | |
| SCHEMBL14039900 | 0.78 | ALDH1A1 (0.50) | KDM4EALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL13739115 | 0.78 | ALDH1A1 (0.55) | KDM4EALDH1A1MAPTDPP4NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2701510-A1 | PYRAZOLOPYRIDAZINES AND METHODS FOR TREATING RETINAL-DEGENERATIVE DISEASES AND HEARING LOSS ASSOCIATED WITH USHER SYNDROME | Usher III Initiative (US) | 2014-03-05 | — | — | EP | disclosed |
| WO-2012148994-A1 | PYRAZOLOPYRIDAZINES AND METHODS FOR TREATING RETINAL-DEGENERATIVE DISEASES AND HEARING LOSS ASSOCIATED WITH USHER SYNDROME | USHER III INITIATIVE (US) | 2012-11-01 | — | — | WO | disclosed |