Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 2/20 | 0.49 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.49 |
| ▸ | SYK | P43405 | 12/20 | 0.42 |
| ▸ | JAK2 | O60674 | 2/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | NNMT | P40261 | 2/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13735485 | 0.86 | MAPK8 (0.51) | MAPK8MAPK9SYKJAK2LRRK2 | |
| SCHEMBL15354455 | 0.77 | MAPK8 (0.63) | MAPK8MAPK9SYK | |
| SCHEMBL15354453 | 0.77 | MAPK8 (0.55) | MAPK8MAPK9SYKJAK2MAPK1 | |
| SCHEMBL26626510 | 0.76 | MAPK8 (0.54) | MAPK8MAPK9SYKJAK2NNMT | |
| SCHEMBL17485379 | 0.76 | MAPK8 (0.54) | MAPK8MAPK9SYKJAK2MAPK1 | |
| SCHEMBL13734182 | 0.73 | MAPK8 (0.52) | MAPK8MAPK9SYKJAK2MAPK1 | |
| SCHEMBL21162236 | 0.71 | MAPK8 (0.56) | MAPK8MAPK9SYK | |
| SCHEMBL13734126 | 0.71 | MAPK8 (0.50) | MAPK8MAPK9SYKJAK2LRRK2 | |
| SCHEMBL30801501 | 0.71 | MAPK8 (0.50) | MAPK8MAPK9SYKJAK2LRRK2 | |
| SCHEMBL14659066 | 0.71 | MAPK8 (0.59) | MAPK8MAPK9SYKNNMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2699553-A1 | SUBSTITUTED DIAMINOCARBOXAMIDE AND DIAMINOCARBONITRILE PYRIMIDINES, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH | Signal Pharmaceuticals, LLC (US) | 2014-02-26 | — | — | EP | disclosed |
| WO-2012145569-A1 | SUBSTITUTED DIAMINOCARBOXAMIDE AND DIAMINOCARBONITRILE PYRIMIDINES, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH | SIGNAL PHARMACEUTICALS, LLC (US) | 2012-10-26 | — | — | WO | disclosed |