SCHEMBL13739747

SCHEMBL13739747

CC(C)S(=O)(=O)n1c(N)nc2ccc(-c3[nH]c(-c4c(F)cccc4F)nc3-c3ccccc3)cc21

nearest known ligand 0.93

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
MAPK14 Q16539 20/20 0.93
CYP3A4 P08684 3/20 0.93

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4838574 0.96 MAPK14 (1.00) MAPK14CYP3A4
Alcohol SCHEMBL4841776 0.92 MAPK14 (0.92) MAPK14CYP3A4
SCHEMBL5770897 0.91 MAPK14 (0.90) MAPK14CYP3A4
SCHEMBL5769141 0.88 MAPK14 (1.00) MAPK14CYP3A4
SCHEMBL5773698 0.87 MAPK14 (0.82) MAPK14CYP3A4
SCHEMBL5772925 0.86 MAPK14 (0.85) MAPK14CYP3A4
SCHEMBL5771483 0.86 MAPK14 (0.91) MAPK14CYP3A4
SCHEMBL5769486 0.85 MAPK14 (0.79) MAPK14CYP3A4
SCHEMBL5771924 0.84 MAPK14 (0.79) MAPK14CYP3A4
SCHEMBL4841627 0.84 MAPK14 (0.79) MAPK14CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2707369-A1 COMPOSITIONS AND METHODS FOR TREATING ALZHEIMER'S DISEASE Eip Pharma, LLC (US) 2014-03-19 EP claimed
WO-2012154814-A1 COMPOSITIONS AND METHODS FOR TREATING ALZHEIMER'S DISEASE EIP PHARMA, LLC (US) 2012-11-15 WO claimed
EP-3081568-B1 COMPOSITIONS AND METHODS FOR TREATING ALZHEIMER'S DISEASE EIP PHARMA LLC (US) 2019-11-13 EP disclosed
US-10441577-B2 Medicament for treatment of liver cancer HELMHOLTZ ZENTRUM FUER INFEKTIONSFORSCHUNG (DE) 2019-10-15 US disclosed
EP-3081568-A1 COMPOSITIONS AND METHODS FOR TREATING ALZHEIMER'S DISEASE Eip Pharma, LLC (US) 2016-10-19 EP disclosed
US-9427438-B2 Compositions and methods for treating Alzheimer's disease EIP PHARMA, LLC (US) 2016-08-30 US disclosed
US-9427438-B2 Compositions and methods for treating Alzheimer's disease EIP PHARMA, LLC (US) 2016-08-30 US disclosed
EP-2707369-B1 COMPOSITIONS AND METHODS FOR TREATING ALZHEIMER'S DISEASE EIP PHARMA LLC (US) 2016-07-27 EP disclosed
US-20160030431-A1 COMPOSITIONS AND METHODS FOR TREATING ALZHEIMER'S DISEASE EIP PHARMA, LLC 2016-02-04 US disclosed
US-20160030431-A1 COMPOSITIONS AND METHODS FOR TREATING ALZHEIMER'S DISEASE EIP PHARMA, LLC 2016-02-04 US disclosed
US-20150079154-A1 MEDICAMENT FOR TREATMENT OF LIVER CANCER HELMHOLTZ-ZENTRUM FUER INFEKTIONSFORSCHUNG GMBH (DE) 2015-03-19 US disclosed
US-20150079154-A1 MEDICAMENT FOR TREATMENT OF LIVER CANCER HELMHOLTZ-ZENTRUM FUER INFEKTIONSFORSCHUNG GMBH (DE) 2015-03-19 US disclosed
US-20140357638-A1 COMPOSITIONS AND METHODS FOR TREATING ALZHEIMER'S DISEASE EIP PHARMA, LLC (US) 2014-12-04 US disclosed
US-20140357638-A1 COMPOSITIONS AND METHODS FOR TREATING ALZHEIMER'S DISEASE EIP PHARMA, LLC (US) 2014-12-04 US disclosed
US-20120289511-A1 COMPOSITIONS AND METHODS FOR TREATING ALZHEIMER'S DISEASE EIP PHARMA, LLC (US) 2012-11-15 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140357638-A1 COMPOSITIONS AND METHODS FOR TREATING ALZHEIMER'S DISEASE APP, PSEN1, PSEN2 MAPK14 4676/4885CYP3A4 4375/4885
US-10441577-B2 Medicament for treatment of liver cancer PYGL, PFKL, GLS2 MAPK14 523/4885CYP3A4 2052/4885
US-20120289511-A1 COMPOSITIONS AND METHODS FOR TREATING ALZHEIMER'S DISEASE APP, PSEN1, PSEN2 MAPK14 4676/4885CYP3A4 4375/4885
US-20150079154-A1 MEDICAMENT FOR TREATMENT OF LIVER CANCER PYGL, PFKL, GLS2 MAPK14 523/4885CYP3A4 2052/4885
US-20160030431-A1 COMPOSITIONS AND METHODS FOR TREATING ALZHEIMER'S DISEASE APP, PSEN1, PSEN2 MAPK14 4676/4885CYP3A4 4375/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.