Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 6/20 | 0.43 |
| ▸ | CHRM5 | P08912 | 5/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 5/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 4/20 | 0.42 |
| ▸ | CHRM4 | P08173 | 4/20 | 0.42 |
| ▸ | DRD2 | P14416 | 4/20 | 0.42 |
| ▸ | DRD4 | P21917 | 4/20 | 0.42 |
| ▸ | DRD3 | P35462 | 4/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.42 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.42 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.42 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.42 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.39 |
| ▸ | HRH1 | P35367 | 2/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | HTR4 | Q13639 | 4/20 | 0.39 |
| ▸ | ACHE | P22303 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3036474 | 0.82 | CHRM1 (0.41) | CHRM1CHRM5CHRM3CHRM2CHRM4 | |
| SCHEMBL2149812 | 0.82 | CHRM1 (0.40) | CHRM1CHRM5CHRM3CHRM2CHRM4 | |
| SCHEMBL2148984 | 0.81 | S1PR1 (0.40) | DRD2DRD4DRD3TSHRNPSR1 | |
| SCHEMBL2149181 | 0.77 | ADRA1D (0.44) | CHRM1CHRM5CHRM3CHRM2CHRM4 | |
| SCHEMBL2149089 | 0.76 | CHRM1 (0.44) | CHRM1CHRM5CHRM3CHRM2CHRM4 | |
| SCHEMBL3041958 | 0.76 | CHRM1 (0.42) | CHRM1CHRM5CHRM3CHRM2CHRM4 | |
| SCHEMBL3031599 | 0.76 | TMEM97 (0.55) | TMEM97 | |
| SCHEMBL2149657 | 0.76 | CHRM1 (0.43) | CHRM1CHRM5CHRM3CHRM2CHRM4 | |
| SCHEMBL2149225 | 0.76 | CHRM1 (0.43) | CHRM1CHRM5CHRM3CHRM2CHRM4 | |
| SCHEMBL2149094 | 0.74 | CHRM1 (0.51) | CHRM1CHRM5CHRM3CHRM2CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090209525-A1 | ENABLING METHODS TO IDENTIFY ALLOSTERIC MODULATORS OF RECEPTOR ACTIVITY | SPALDING TRACY A | 2009-08-20 | — | — | US | disclosed |
| US-20090209525-A1 | ENABLING METHODS TO IDENTIFY ALLOSTERIC MODULATORS OF RECEPTOR ACTIVITY | SPALDING TRACY A | 2009-08-20 | — | — | US | disclosed |
| WO-2008005063-A2 | ENABLING METHODS TO IDENTIFY ALLOSTERIC MODULATORS OF RECEPTOR ACTIVITY | ACADIA PHARMACEUTICALS INC. (US) | 2008-01-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090209525-A1 | ENABLING METHODS TO IDENTIFY ALLOSTERIC MODULATORS OF RECEPTOR ACTIVITY | GRK2, GRM2, GRK4 | CHRM1 587/4885CHRM5 347/4885CHRM3 245/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.