ADRA1D

Alpha-1D adrenergic receptor · P25100 · ADRA1D on Sugi Atlas →

207,676 patent compounds predicted against ADRA1D, 138,926 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Brimonidine (SCHEMBL24670)	1.00	15/20
Brimonidine (SCHEMBL34648)	0.84	15/20
Brimonidine (SCHEMBL34647)	1.00	14/20
Brimonidine (SCHEMBL34649)	1.00	14/20
Labetalol (SCHEMBL41230)	1.00	13/20
Labetalol (SCHEMBL4582)	1.00	12/20
Labetalol (SCHEMBL41231)	1.00	12/20
Protokylol (SCHEMBL50567)	0.76	11/20
Tamsulosin (SCHEMBL34378)	1.00	9/20
Tamsulosin (SCHEMBL53998)	1.00	9/20
Tamsulosin (SCHEMBL23428)	0.98	9/20
Tamsulosin (SCHEMBL23429)	0.96	9/20
Dexmedetomidine (SCHEMBL26433)	1.00	8/20
Phentolamine (SCHEMBL40852)	0.87	8/20
SCHEMBL51245	0.67	8/20
Tizanidine (SCHEMBL60334)	0.58	7/20
SCHEMBL50239	0.66	6/20
Phentolamine (SCHEMBL5653)	1.00	5/20
Oxymetazoline (SCHEMBL24301)	1.00	5/20
Olanzapine (SCHEMBL28763)	1.00	5/20

Clinical trials — most relevant to ADRA1D by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Reversal of Acute β-Blocker Induced Bronchoconstriction	PHASE4	COMPLETED
The Cardiopulmonary Effect of Inhaled Beta-2-agonists on Adult Patients Born With Ventricular Septum Defects.	PHASE4	COMPLETED
Medical Stone Expulsive Therapy for Acutely Obstructed Ureteric Calculi	PHASE4	COMPLETED
Sympathetic Neurovascular Transduction: Role of Adrenergic Receptors and Sex Differences	PHASE4	RECRUITING
Dexmedetomidine Adjuvant Treatment for Depressed Patients Undergoing ECT	PHASE4	UNKNOWN
Clonidine vs. Dexmedetomidine in Agitated Delirium in Intensive Care Patients	PHASE4	UNKNOWN
Lidocaine vs. Lidocaine With Dexmedetomidine for Intravenous Regional Anesthesia (IVRA) in Upper Limb Surgery	PHASE4	RECRUITING
Effect of Esmolol on Oxygenation Index in Patients With Acute Respiratory Distress Syndrome	PHASE3	RECRUITING
A Study to Compare the Effects of Coreg CR and Coreg IR on Heart Function in Subjects With Stable Chronic Heart Failure	PHASE3	COMPLETED
Use of Dexmedetomidine to Improve Pain Control and Recovery After Laparocopic-Assisted Bowel Surgery in Adults	PHASE3	NOT_YET_RECRUITING
Dexmedetomidine and Outcomes of Cardiac Surgery (DOCS)	PHASE2/PHASE3	COMPLETED
Prazosin for Alcohol Dependence and Posttraumatic Stress Disorder	PHASE2	COMPLETED
A Pilot Study to Investigate Fenoldopam Usage in the Prevention of Postoperative Renal Dysfunction in Patients at a High Risk for Renal Impairment During Cariopulmonary Bypass for Cardiac Surgery	PHASE2	COMPLETED
Analgesia After Laparoscopic Cholecystectomy	PHASE2	UNKNOWN
Biased GRK Signaling Via β2-Adrenergic Receptors in Human Skeletal Muscle	PHASE2	NOT_YET_RECRUITING
Selective β2-AR Antagonism in Asthma	PHASE1	COMPLETED
Dose Response and Receptor Selectivity of Beta-blocker Effects on Bone Metabolism	EARLY_PHASE1	COMPLETED
Influence of Genetic Polymorphisms on Ventricular Structure and Function in Patients With Single Ventricle Anatomy	nan	COMPLETED
Genetic Influences of Albuterol Response In Children With Bronchiolitis	nan	COMPLETED
Brain Receptors in Sympathetic Nervous System Regulation	nan	COMPLETED
Clinical Effect and Safety of Tamsulosin 0.4mg in Patients With LUTS/BPH Refractory to Tamsulosin 0.2mg	nan	UNKNOWN
Can Caudal Dexmedetomidine Provide Effective Analgesia?	nan	NOT_YET_RECRUITING
Renal Denervation in Patients With Chronic Heart Failure	nan	WITHDRAWN
The Impact of Early Norepinephrine Administration on Outcomes of Patients With Sepsis-induced Hypotension	nan	COMPLETED
The Mechanism of Endogenous Nociceptin/Orphanin FQ(N/OFQ) and β1-adrenoceptor Autoantibody in Promoting Ischemic Arrhythmia in Rats	nan	NOT_YET_RECRUITING
Influence of Nebivolol on Postmenopausal Women	nan	UNKNOWN
The Locus Coeruleus, Norepinephrine and Cognitive Aging	nan	ACTIVE_NOT_RECRUITING
Acute Airway Vascular Smooth Muscle Effects of Inhaled Budesonide	nan	COMPLETED
The Influence of Beta Blocker Therapy on the Hemodynamic Response to Inotrope Infusion in Patients With Acute Decompensated Heart Failure	nan	COMPLETED
Comparison of Milrinone and Epinephrine on TAPSE	nan	NOT_YET_RECRUITING

Related proteins — ESM-2 sequence neighbours (a ADRA1D binder may also engage these)

Protein	Name	Similarity
P97714	—	1.000	P97714 →
P23944	—	1.000	P23944 →
Q9TTM9	—	1.000	Q9TTM9 →
O02666	—	1.000	O02666 →
Q9TT96	—	0.994	Q9TT96 →
Q28998	—	0.993	Q28998 →
P34971	—	0.992	P34971 →
ADRA2C	Alpha-2C adrenergic receptor	0.992	landscape →
Q28838	—	0.991	Q28838 →
P11615	—	0.991	P11615 →
P18871	—	0.991	P18871 →
Q60474	—	0.990	Q60474 →
Q9TST6	—	0.989	Q9TST6 →
P79148	—	0.988	P79148 →
P15823	—	0.988	P15823 →
ADRB1	Beta-1 adrenergic receptor	0.987	landscape →
Q8IZ08	—	0.987	Q8IZ08 →
Q60476	—	0.987	Q60476 →
P47899	—	0.986	P47899 →
P22086	—	0.986	P22086 →
Q7TQN7	—	0.986	Q7TQN7 →
ADRA2A	Alpha-2A adrenergic receptor	0.986	landscape →
Q01337	—	0.986	Q01337 →
P19328	—	0.985	P19328 →
P18090	—	0.985	P18090 →
ADRA1B	Alpha-1B adrenergic receptor	0.985	landscape →
P22909	—	0.985	P22909 →
Q01338	—	0.985	Q01338 →
O19012	—	0.985	O19012 →
O19025	—	0.984	O19025 →