Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPRT1 | P00492 | 5/20 | 0.44 |
| ▸ | NT5E | P21589 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.36 |
| ▸ | PNP | P00491 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 4/20 | 0.35 |
| ▸ | HSP90AB1 | P08238 | 4/20 | 0.35 |
| ▸ | FDPS | P14324 | 1/20 | 0.34 |
| ▸ | CDK1 | P06493 | 1/20 | 0.34 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.34 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13743182 | 0.90 | HPRT1 (0.45) | HPRT1NT5EFGFR1SLC22A6PNP | |
| SCHEMBL13714779 | 0.88 | HPRT1 (0.43) | HPRT1NT5EHDAC6HDAC1HDAC4 | |
| SCHEMBL13742950 | 0.83 | POLB (0.52) | HPRT1NT5ECDK2 | |
| SCHEMBL3854698 | 0.80 | HPRT1 (0.40) | HPRT1NT5EHDAC6HDAC1HDAC4 | |
| SCHEMBL3863287 | 0.79 | HPRT1 (0.37) | HPRT1NT5EHDAC6HDAC1HDAC4 | |
| SCHEMBL3850987 | 0.78 | HDAC6 (0.45) | HPRT1NT5EHDAC6HDAC1HDAC4 | |
| SCHEMBL13714781 | 0.78 | HPRT1 (0.44) | HPRT1NT5EFGFR1SLC22A6PNP | |
| SCHEMBL3853182 | 0.78 | HPRT1 (0.44) | HPRT1NT5EFGFR1SLC22A6PNP | |
| SCHEMBL385550 | 0.77 | CYP3A4 (0.45) | HPRT1NT5EHDAC6HDAC1HDAC4 | |
| SCHEMBL3942848 | 0.75 | HSP90AB1 (0.44) | HDAC6HDAC1HDAC4FGFR1SLC22A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7579332-B2 | Nucleobase phosphonate analogs for antiviral treatment | GILEAD SCIENCES, INC. (US) | 2009-08-25 | — | — | US | disclosed |