Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | HPRT1 | P00492 | 1/20 | 0.43 |
| ▸ | CDK1 | P06493 | 3/20 | 0.43 |
| ▸ | CDK2 | P24941 | 3/20 | 0.43 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.43 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.43 |
| ▸ | NT5E | P21589 | 1/20 | 0.42 |
| ▸ | HSP90AB1 | P08238 | 11/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 10/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | PRKACA | P17612 | 1/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.38 |
| ▸ | PRKACG | P22612 | 1/20 | 0.38 |
| ▸ | PRKACB | P22694 | 1/20 | 0.38 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.38 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17601915 | 0.86 | CYP3A4 (0.43) | CYP3A4HPRT1CDK1CDK2CCNB1 | |
| SCHEMBL6902158 | 0.81 | CYP3A4 (0.65) | CYP3A4HPRT1HSP90AB1HSP90AA1HDAC4 | |
| SCHEMBL6902140 | 0.81 | CYP3A4 (0.65) | CYP3A4HPRT1HSP90AB1HSP90AA1HDAC4 | |
| SCHEMBL3852462 | 0.79 | CYP3A4 (0.46) | CYP3A4HSP90AB1HSP90AA1HDAC4HDAC1 | |
| SCHEMBL3855208 | 0.79 | CYP3A4 (0.46) | CYP3A4HSP90AB1HSP90AA1HDAC4HDAC1 | |
| SCHEMBL3852447 | 0.79 | CYP3A4 (0.46) | CYP3A4HSP90AB1HSP90AA1HDAC4HDAC1 | |
| SCHEMBL886938 | 0.78 | CYP3A4 (0.67) | CYP3A4 | |
| SCHEMBL17599288 | 0.78 | HPRT1 (0.38) | CYP3A4HPRT1CDK1CDK2CCNB1 | |
| SCHEMBL13742912 | 0.77 | HPRT1 (0.44) | HPRT1CDK1CDK2CCNB1CCNE1 | |
| SCHEMBL31058756 | 0.76 | CDK1 (0.54) | CDK1CDK2CCNB1CCNE1HSP90AB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11572377-B2 | Nucleotide analogs | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2023-02-07 | — | — | US | disclosed |
| US-20220395510-A1 | Nucleotide Analogs | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS, OFFICE OF THE GENERAL COUNSEL (024) | 2022-12-15 | — | — | US | disclosed |
| US-11344555-B2 | Nucleotide analogs | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2022-05-31 | — | — | US | disclosed |
| EP-3194411-B1 | NUCLEOTIDE ANALOGS | UNIV CALIFORNIA (US) | 2022-05-04 | — | — | EP | disclosed |
| US-20220072004-A1 | Nucleotide Analogs | THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS | 2022-03-10 | — | — | US | disclosed |
| EP-3350191-B9 | NUCLEOTIDE ANALOGS | UNIV CALIFORNIA (US) | 2021-12-22 | — | — | EP | disclosed |
| EP-3875462-A1 | NUCLEOTIDE ANALOGS | The Regents of The University of California (US) | 2021-09-08 | — | — | EP | disclosed |
| US-20210246153-A1 | Nucleotide Analogs | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2021-08-12 | — | — | US | disclosed |
| US-11014950-B2 | Nucleotide analogs | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2021-05-25 | — | — | US | disclosed |
| EP-3350191-B1 | NUCLEOTIDE ANALOGS | UNIV CALIFORNIA (US) | 2021-05-12 | — | — | EP | disclosed |
| WO-2017048956-A1 | NUCLEOTIDE ANALOGS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2017-03-23 | — | — | WO | disclosed |
| US-20170037068-A1 | NUCLEOTIDE ANALOGS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2017-02-09 | — | — | US | disclosed |
| US-9493493-B2 | Nucleotide analogs | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2016-11-15 | — | — | US | disclosed |
| WO-2016044281-A1 | NUCLEOTIDE ANALOGS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2016-03-24 | — | — | WO | disclosed |
| US-20160083407-A1 | NUCLEOTIDE ANALOGS | THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS | 2016-03-24 | — | — | US | disclosed |
| EP-1831235-B1 | LUNG-TARGETED DRUGS | UNIV CALIFORNIA (US) | 2013-02-20 | — | — | EP | disclosed |
| US-8101745-B2 | Conjugate cidofovir, idoxuridine, vidarabine, trifluridine, acyclovir, famciclovir penciclovir, valacyclovir, ganciclovir, antiviral, antimicrobial, cancer drug of interest to glycerol ethers or glycerol phosphate ethers | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2012-01-24 | — | — | US | disclosed |
| US-20080221061-A1 | Lung-Targeted Drugs | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2008-09-11 | — | — | US | disclosed |
| EP-1831235-A2 | LUNG-TARGETED DRUGS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2007-09-12 | — | — | EP | disclosed |
| WO-2006066074-A2 | LUNG-TARGETED DRUGS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2006-06-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11572377-B2 | Nucleotide analogs | NUDT1, DUT, DPYD | CYP3A4 3875/4885HPRT1 52/4885CDK1 1675/4885 |
| US-20080221061-A1 | Lung-Targeted Drugs | DGKG, GK, PHOSPHO1 | CYP3A4 3814/4885HPRT1 3277/4885CDK1 1683/4885 |
| US-11014950-B2 | Nucleotide analogs | NUDT1, DUT, DPYD | CYP3A4 3875/4885HPRT1 52/4885CDK1 1675/4885 |
| US-20220395510-A1 | Nucleotide Analogs | NUDT1, DUT, DPYD | CYP3A4 3875/4885HPRT1 52/4885CDK1 1675/4885 |
| US-20220072004-A1 | Nucleotide Analogs | NUDT1, DUT, DPYD | CYP3A4 3875/4885HPRT1 52/4885CDK1 1675/4885 |
| US-20160083407-A1 | NUCLEOTIDE ANALOGS | NUDT1, DUT, DPYD | CYP3A4 3875/4885HPRT1 52/4885CDK1 1675/4885 |
| US-11344555-B2 | Nucleotide analogs | NUDT1, DUT, DPYD | CYP3A4 3875/4885HPRT1 52/4885CDK1 1675/4885 |
| US-20170037068-A1 | NUCLEOTIDE ANALOGS | NUDT1, DUT, DPYD | CYP3A4 3875/4885HPRT1 52/4885CDK1 1675/4885 |
| US-20210246153-A1 | Nucleotide Analogs | NUDT1, DUT, DPYD | CYP3A4 3875/4885HPRT1 52/4885CDK1 1675/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.