⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29054509 | 0.83 | — | — | |
| SCHEMBL14554722 | 0.80 | THRB (0.38) | — | |
| SCHEMBL14707865 | 0.80 | THRB (0.38) | — | |
| SCHEMBL11946929 | 0.80 | THRB (0.38) | — | |
| SCHEMBL14554567 | 0.80 | THRB (0.38) | — | |
| SCHEMBL14707864 | 0.80 | THRB (0.38) | — | |
| SCHEMBL11953949 | 0.80 | THRB (0.38) | — | |
| SCHEMBL11953952 | 0.80 | THRB (0.38) | — | |
| SCHEMBL14555942 | 0.80 | THRB (0.38) | — | |
| SCHEMBL11946967 | 0.80 | THRB (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230135152-A1 | PIKFYVE KINASE INHIBITORS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2023-05-04 | — | — | US | disclosed |
| WO-2021163727-A1 | PIKFYVE KINASE INHIBITORS | AcuraStem Incorporated (US) | 2021-08-19 | — | — | WO | disclosed |
| US-20170145046-A1 | 6-ETHER/THIOETHER-PURINES AS TOPOISOMERASE II CATALYTIC INHIBITORS AND THEIR USE IN THERAPY | CLINIGEN GROUP PLC (GB) | 2017-05-25 | — | — | US | disclosed |
| US-20140031539-A1 | 6-ETHER/THIOETHER-PURINES AS TOPOISOMERASE II CATALYTIC INHIBITORS AND THEIR USE IN THERAPY | Biocodex, Inc (US) | 2014-01-30 | — | — | US | disclosed |
| US-20090209535-A1 | 6-ETHER/THIOETHER-PURINES AS TOPOISOMERASE II CATALYTIC INHIBITORS AND THEIR USE IN THERAPY | TOPOTARGET A/S (DK) | 2009-08-20 | — | — | US | disclosed |