Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTRA2 | O43464 | 8/20 | 0.59 |
| ▸ | HTRA1 | Q92743 | 8/20 | 0.59 |
| ▸ | ALB | P02768 | 2/20 | 0.51 |
| ▸ | PSMB5 | P28074 | 6/20 | 0.51 |
| ▸ | PSMB2 | P49721 | 3/20 | 0.51 |
| ▸ | PSMB1 | P20618 | 2/20 | 0.51 |
| ▸ | PSMB8 | P28062 | 2/20 | 0.51 |
| ▸ | PSMB10 | P40306 | 2/20 | 0.51 |
| ▸ | PSMB11 | A5LHX3 | 1/20 | 0.51 |
| ▸ | PSMD11 | O00231 | 1/20 | 0.51 |
| ▸ | PSMD12 | O00232 | 1/20 | 0.51 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.51 |
| ▸ | PSMA7 | O14818 | 1/20 | 0.51 |
| ▸ | PSMD3 | O43242 | 1/20 | 0.51 |
| ▸ | CTSB | P07858 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | PSMC3 | P17980 | 1/20 | 0.51 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.51 |
| ▸ | CYP3A7 | P24462 | 1/20 | 0.51 |
| ▸ | PSMA1 | P25786 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13743070 | 0.96 | HTRA2 (0.54) | HTRA2HTRA1ALBPSMB5PSMB2 | |
| SCHEMBL13743312 | 0.94 | HTRA2 (0.59) | HTRA2HTRA1ALBPSMB5PSMB2 | |
| SCHEMBL13743295 | 0.90 | HTRA2 (0.54) | HTRA2HTRA1ALBPSMB5PSMB2 | |
| SCHEMBL13742963 | 0.81 | HTRA2 (0.46) | HTRA2HTRA1PSMB5PSMB2PSMB1 | |
| SCHEMBL17298374 | 0.80 | PSMB5 (0.67) | PSMB5PSMB2PSMB1PSMB8PSMB10 | |
| SCHEMBL17298373 | 0.77 | PSMB5 (0.69) | PSMB5PSMB2PSMB1PSMB8PSMB10 | |
| SCHEMBL18859012 | 0.74 | PSMB5 (0.63) | PSMB5PSMB2PSMB1PSMB8PSMB10 | |
| SCHEMBL17298540 | 0.74 | PSMB5 (0.70) | PSMB5PSMB2PSMB1PSMB8PSMB10 | |
| SCHEMBL18835545 | 0.74 | PSMB5 (0.66) | PSMB5PSMB2PSMB1PSMB8PSMB10 | |
| SCHEMBL18835528 | 0.73 | PSMB5 (0.75) | PSMB5PSMB2PSMB1PSMB8PSMB10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090215093-A1 | COMPOUNDS FOR ENZYME INHIBITION | PROTEOLIX, INC. (US) | 2009-08-27 | — | — | US | disclosed |
| US-20090215093-A1 | COMPOUNDS FOR ENZYME INHIBITION | PROTEOLIX, INC. (US) | 2009-08-27 | — | — | US | disclosed |