Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | FAAH | O00519 | 1/20 | 0.41 |
| ▸ | CCR1 | P32246 | 2/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13744070 | 0.84 | POLB (0.48) | POLBSMN1; SMN2KMT2ALMNAMAPT | |
| SCHEMBL1712628 | 0.83 | FAAH (0.51) | POLBSMN1; SMN2KMT2ALMNAMAPT | |
| SCHEMBL1713125 | 0.82 | POLB (0.53) | POLBSMN1; SMN2KMT2ALMNAMAPT | |
| SCHEMBL1713030 | 0.82 | CNR1 (0.56) | POLBSMN1; SMN2KMT2ALMNAMAPT | |
| SCHEMBL1722857 | 0.81 | CNR1 (0.56) | POLBSMN1; SMN2KMT2ALMNAMAPT | |
| SCHEMBL1713307 | 0.80 | POLB (0.56) | POLBSMN1; SMN2KMT2ALMNAMAPT | |
| SCHEMBL1713229 | 0.79 | POLB (0.55) | POLBSMN1; SMN2KMT2ALMNAMAPT | |
| SCHEMBL5286229 | 0.78 | POLB (0.55) | POLBSMN1; SMN2KMT2ALMNAMAPT | |
| SCHEMBL1712996 | 0.77 | POLB (0.50) | POLBSMN1; SMN2KMT2ALMNAMAPT | |
| SCHEMBL5246776 | 0.74 | POLB (0.75) | POLBSMN1; SMN2KMT2ALMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009100994-A1 | PIPERIDINE SULFONAMIDE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2009-08-20 | — | — | WO | disclosed |