Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | PNP | P00491 | 1/20 | 0.34 |
| ▸ | AR | P10275 | 2/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | HCAR1 | Q9BXC0 | 3/20 | 0.33 |
| ▸ | XDH | P47989 | 2/20 | 0.33 |
| ▸ | ASPH | Q12797 | 1/20 | 0.33 |
| ▸ | MASP2 | O00187 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19770361 | 0.80 | KDM4E (0.37) | KDM4EALDH1A1HSD17B10LMNAGLA | |
| SCHEMBL1373788 | 0.76 | MASP2 (0.33) | KDM4EALDH1A1LMNAMAPTHPGD | |
| SCHEMBL11542411 | 0.72 | — | — | |
| SCHEMBL12820646 | 0.72 | — | — | |
| SCHEMBL7513080 | 0.70 | — | — | |
| SCHEMBL20589156 | 0.70 | MASP2 (0.38) | KDM4EALDH1A1MEN1MAPTKMT2A | |
| Hydrochloric Acid SCHEMBL22188751 | 0.70 | MASP2 (0.38) | KDM4EALDH1A1MEN1MAPTKMT2A | |
| SCHEMBL162683 | 0.68 | — | — | |
| SCHEMBL3256572 | 0.68 | — | — | |
| SCHEMBL9653828 | 0.68 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2367799-B1 | 2-AMINO-5-TRIFLUOROMETHYL-PYRIMIDINE DERIVATIVES AND THEIR USE AS PTK2 KINASE INHIBITORS | IPHARMA H K LTD (HK) | 2018-08-01 | — | — | EP | disclosed |
| US-8785464-B2 | Pyrimidine derivatives that inhibit FAK/PTK2 | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-07-22 | — | — | US | disclosed |
| US-20140038993-A1 | NEW COMPOUNDS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-02-06 | — | — | US | disclosed |
| US-20110288109-A1 | NEW COMPOUNDS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-11-24 | — | — | US | disclosed |
| EP-2367799-A1 | NEW COMPOUNDS | Boehringer Ingelheim International GmbH (DE) | 2011-09-28 | — | — | EP | disclosed |
| WO-2010058030-A1 | NEW COMPOUNDS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-05-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110288109-A1 | NEW COMPOUNDS | MKI67, CCNA1, CCNT1 | KDM4E 3513/4885ALDH1A1 248/4885HSD17B10 1972/4885 |
| US-20140038993-A1 | NEW COMPOUNDS | MKI67, CCNA1, CCNT1 | KDM4E 3398/4885ALDH1A1 218/4885HSD17B10 2071/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.