MASP2 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL405483	0.52	16/20
SCHEMBL1433111	0.52	5/20
SCHEMBL1432531	0.44	5/20
SCHEMBL1432535	0.44	5/20
SCHEMBL1431802	0.47	4/20
SCHEMBL1433338	0.45	4/20
SCHEMBL1162981	0.45	4/20
SCHEMBL1432494	0.41	4/20
SCHEMBL1431847	0.41	4/20
SCHEMBL1066515	1.00	3/20
SCHEMBL1433255	0.52	3/20
SCHEMBL1432469	0.51	3/20
SCHEMBL1432472	0.51	3/20
SCHEMBL1432474	0.51	3/20
SCHEMBL1328105	0.51	3/20
SCHEMBL1432206	0.51	3/20
Hydrochloric Acid (SCHEMBL1432141)	0.47	3/20
SCHEMBL1431845	0.45	3/20
SCHEMBL1434273	0.45	3/20
SCHEMBL1433580	0.44	3/20

Clinical trials — most relevant to MASP2 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
PROlectin M, a Nucleocapsid TErminal GaleCTin Antagonist for COVID-19	PHASE3	UNKNOWN
Clinical Trial With Aprotinin in the Acute Respiratory Distress Syndrome Treatment	PHASE3	NOT_YET_RECRUITING
Angiotensin-(1,7) Treatment in COVID-19: the ATCO Trial	PHASE2/PHASE3	UNKNOWN
Study on Mannan Binding Lectin (MBL) Substitution in MBL-Deficient Children With Chemotherapy-Induced Neutropenia	PHASE2	COMPLETED
Angiotensin 1-7 as a Therapy in the Treatment of COVID-19	PHASE2	UNKNOWN
NestaCell® Mesenchymal Stem Cell to Treat Patients With Severe COVID-19 Pneumonia	PHASE2	COMPLETED
Clinical Assessment of Oral Lactoferrin as a Safe Antiviral and Immunoregulatory in Treating COVID-19 Disease	PHASE2	UNKNOWN
CINRYZE as a Donor Pre-treatment Strategy in Kidney Recipients of KDPI>60%	PHASE1	UNKNOWN
Trial of Alpha One Antitrypsin Inhalation in Treating Patient With Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)	EARLY_PHASE1	UNKNOWN
Significance of Ficolin 2 in the Determination of Serological Activity in Chronic Inflammatory Bowel Disease	nan	COMPLETED
Study of the Level of a Protein Which Could Predict the Development of a Fungal Infection in Patients With Acute Leukemia	nan	COMPLETED
The Natural History of Alpha-Mannosidosis	nan	COMPLETED
Disorders of the Acute Phase Response Following Trauma and Invasive Surgery	nan	ENROLLING_BY_INVITATION
Association Between Plasma Level of Mannose Binding Lectin and Human Reproduction	nan	RECRUITING
Impact of the Genetic Polymorphism on COVID-19 in Egypt	nan	UNKNOWN
Observational Study of Sepsis and Pneumonia to Develop Diagnostic Tests	nan	UNKNOWN
Study of PNPLA3 Genetic Polymorphisms in Patients With Non-Alcoholic Fatty Liver Disease in an Ultramarine Population (AdipoDROMExpo)	nan	RECRUITING
Biomarker for Mannosidosis Disease (BioMannosidosis)	nan	WITHDRAWN
Biomarkers of Lichen Sclerosus	nan	UNKNOWN
Cardiac Injury in COVID-19: a Pathology Study	nan	UNKNOWN
Testicular Proteins for Sperm Retrieval Prediction Protein1, Testis-Expressed Gene 101, and Lectin Galactoside-binding Protein in Predicting Surgical Sperm Retrieval in Men With Non-Obstructive Azoospermia	nan	UNKNOWN
Clinical Status and Bronchial Inflammation in Patients With Bronchiolitis Obliterans	nan	COMPLETED
Influence of Statins in Artery Aneurysms	nan	UNKNOWN
The Role of Galectins in the Non-invasive Diagnosis of Endometriosis	nan	UNKNOWN
Role of Microparticles in Covid-19 Infection	nan	COMPLETED
Correlation Between Serum Markers of Unstable Plaque and Virtual Histology of Unstable Plaque Visualized by IVUS	nan	COMPLETED
Low Plasma Mannose Binding Lectin (p-MBL) Level is a Risk Factor for Recurrent Pregnancy Loss (RPL)	nan	COMPLETED
Bioelectrical Impedance in Monitoring Hyperhydration and Polyneuromyopathy in Critically Ill Patients	nan	COMPLETED
SerpinB3 Expression, PAR2 and SCCA-PD Polymorphism in Acute Respiratory Distress Syndrome	nan	RECRUITING
Histoblood Group Antigens as a Risk Factor of Asthma	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a MASP2 binder may also engage these)

Protein	Name	Similarity
Q91WP0	—	0.998	Q91WP0 →
P98064	—	0.991	P98064 →
P48740	—	0.991	P48740 →
Q9JJS8	—	0.990	Q9JJS8 →
Q8CHN8	—	0.988	Q8CHN8 →
P59511	—	0.968	P59511 →
Q8CFG9	—	0.967	Q8CFG9 →
Q9QWJ9	—	0.967	Q9QWJ9 →
Q9QYP2	—	0.967	Q9QYP2 →
Q4VC17	—	0.966	Q4VC17 →
Q9QZS7	—	0.965	Q9QZS7 →
Q61220	—	0.965	Q61220 →
Q8WXS8	—	0.965	Q8WXS8 →
Q8CFG8	—	0.965	Q8CFG8 →
Q5R544	—	0.964	Q5R544 →
A2VCU8	—	0.964	A2VCU8 →
Q5R1W3	—	0.964	Q5R1W3 →
P57110	—	0.964	P57110 →
Q8TE58	—	0.963	Q8TE58 →
Q62918	—	0.963	Q62918 →
NRP1	Neuropilin-1	0.963	landscape →
Q69DK8	—	0.962	Q69DK8 →
C1S	Complement C1s subcomponent	0.962	landscape →
ADAMTS1	A disintegrin and metalloproteinase with thrombospondin motifs 1	0.962	landscape →
Q90827	—	0.962	Q90827 →
A2ARA8	—	0.962	A2ARA8 →
P85171	—	0.962	P85171 →
Q4R577	—	0.962	Q4R577 →
O08859	—	0.961	O08859 →
A6QR11	—	0.961	A6QR11 →