Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 10/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.32 |
| ▸ | ATR | Q13535 | 2/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | HSD17B13 | Q7Z5P4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3720955 | 0.92 | TYK2 (0.38) | TYK2PDE4DATR | |
| SCHEMBL3774212 | 0.85 | ATR (0.38) | TYK2PDE4DSMN1; SMN2ATRRAB9A | |
| SCHEMBL3722959 | 0.85 | TYK2 (0.33) | TYK2GSK3BPDE4DSMN1; SMN2ATR | |
| SCHEMBL3719904 | 0.84 | MEN1 (0.40) | TYK2SMN1; SMN2L3MBTL1RAB9AMEN1 | |
| SCHEMBL3720274 | 0.84 | TYK2 (0.40) | TYK2PDE4DSMN1; SMN2ATRRAB9A | |
| SCHEMBL3726335 | 0.83 | ATR (0.35) | TYK2GSK3BATR | |
| SCHEMBL3719028 | 0.83 | TGFBR1 (0.34) | TYK2GSK3BPDE4DATRMEN1 | |
| SCHEMBL3724344 | 0.82 | TYK2 (0.36) | TYK2PDE4DATR | |
| SCHEMBL3730986 | 0.82 | TGFBR1 (0.37) | TYK2GSK3BPDE4DNUDT1ATR | |
| SCHEMBL3663899 | 0.82 | MCL1 (0.38) | SMN1; SMN2NUDT1ATRRAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009100375-A1 | SUBSTITUTED IMIDAZOPYRIDAZINES USEFUL AS KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-08-13 | — | — | WO | disclosed |