Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 14/20 | 0.63 |
| ▸ | TTK | P33981 | 3/20 | 0.44 |
| ▸ | STAT3 | P40763 | 1/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.42 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.41 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3731596 | 0.93 | TYK2 (0.53) | TYK2STAT3PDE4D | |
| SCHEMBL3731587 | 0.93 | TYK2 (0.53) | TYK2STAT3PDE4D | |
| SCHEMBL13013308 | 0.93 | TYK2 (0.53) | TYK2STAT3PDE4D | |
| SCHEMBL13013392 | 0.92 | TYK2 (0.55) | TYK2STAT3PDE4D | |
| SCHEMBL3721108 | 0.92 | TYK2 (0.55) | TYK2STAT3PDE4D | |
| SCHEMBL3721100 | 0.92 | TYK2 (0.55) | TYK2STAT3PDE4D | |
| SCHEMBL13062593 | 0.91 | TYK2 (0.52) | TYK2TTKSTAT3PDE4D | |
| SCHEMBL14732099 | 0.91 | TYK2 (0.52) | TYK2TTKSTAT3PDE4D | |
| SCHEMBL14732080 | 0.91 | TYK2 (0.52) | TYK2STAT3PDE4D | |
| SCHEMBL14732081 | 0.91 | TYK2 (0.52) | TYK2STAT3PDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2240488-B1 | SUBSTITUTED IMIDAZOPYRIDAZINES USEFUL AS KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2016-11-02 | — | — | EP | disclosed |
| WO-2009100375-A1 | SUBSTITUTED IMIDAZOPYRIDAZINES USEFUL AS KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-08-13 | — | — | WO | disclosed |