Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 18/20 | 0.52 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.42 |
| ▸ | STAT3 | P40763 | 1/20 | 0.41 |
| ▸ | TTK | P33981 | 1/20 | 0.38 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | FLT3 | P36888 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13062593 | 1.00 | TYK2 (0.52) | TYK2PDE4DSTAT3TTKCCNE1 | |
| SCHEMBL13745103 | 0.91 | TYK2 (0.63) | TYK2PDE4DSTAT3TTK | |
| SCHEMBL3775460 | 0.90 | TYK2 (0.49) | TYK2PDE4DTTK | |
| SCHEMBL3775463 | 0.90 | TYK2 (0.49) | TYK2PDE4DTTK | |
| SCHEMBL3773609 | 0.90 | TYK2 (0.49) | TYK2PDE4DSTAT3TTK | |
| SCHEMBL3773610 | 0.90 | TYK2 (0.49) | TYK2PDE4DSTAT3TTK | |
| SCHEMBL3772384 | 0.90 | TYK2 (0.52) | TYK2PDE4DSTAT3TTKCCNE1 | |
| SCHEMBL3772377 | 0.90 | TYK2 (0.52) | TYK2PDE4DSTAT3TTKCCNE1 | |
| SCHEMBL3731587 | 0.90 | TYK2 (0.53) | TYK2PDE4DSTAT3 | |
| SCHEMBL3731596 | 0.90 | TYK2 (0.53) | TYK2PDE4DSTAT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2240488-B1 | SUBSTITUTED IMIDAZOPYRIDAZINES USEFUL AS KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2016-11-02 | — | — | EP | claimed |
| US-8389527-B2 | Substituted imidazopyridazines useful as kinase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2013-03-05 | — | — | US | claimed |
| EP-2240488-B1 | SUBSTITUTED IMIDAZOPYRIDAZINES USEFUL AS KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2016-11-02 | — | — | EP | disclosed |