SCHEMBL13745218

SCHEMBL13745218

COc1cccc(-c2cc(F)c(OC)cc2N)n1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSP90AA1 P07900 4/20 0.39
HSP90AB1 P08238 3/20 0.39
TRAP1 Q12931 1/20 0.39
MEN1 O00255 1/20 0.39
NPC1 O15118 1/20 0.39
ALDH1A1 P00352 1/20 0.39
RAB9A P51151 1/20 0.39
KMT2A Q03164 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.39
NOS1 P29475 4/20 0.38
BTK Q06187 1/20 0.38
CYP3A4 P08684 1/20 0.37
TDP1 Q9NUW8 1/20 0.37
MAP4K1 Q92918 1/20 0.37
TGFBR1 P36897 1/20 0.36
NR4A2 P43354 1/20 0.36
DHODH Q02127 1/20 0.36
NOS3 P29474 2/20 0.36
HSD17B14 Q9BPX1 1/20 0.35
RPS6KA2 Q15349 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10305014 0.84 FFAR1 (0.39) HSP90AA1HSP90AB1TRAP1NPC1ALDH1A1
SCHEMBL13745638 0.80 ATR (0.41) NOS1BTKTGFBR1NOS3
SCHEMBL13745269 0.79 HSP90AA1 (0.50) HSP90AA1HSP90AB1TRAP1BTK
SCHEMBL2652553 0.77 HSP90AA1 (0.40) HSP90AA1HSP90AB1TRAP1NPC1ALDH1A1
SCHEMBL13746030 0.75 HSP90AA1 (0.49) HSP90AA1HSP90AB1TRAP1NPC1ALDH1A1
SCHEMBL16068078 0.73 GPBAR1 (0.45) HSP90AA1HSP90AB1TRAP1RAB9ABTK
SCHEMBL15624618 0.71 MEN1 (0.48) HSP90AA1HSP90AB1MEN1NPC1ALDH1A1
SCHEMBL15624615 0.71 ATR (0.39) BTKMAP4K1RPS6KA2
SCHEMBL9981152 0.71 OXTR (0.42) HSP90AA1HSP90AB1TRAP1BTKTGFBR1
SCHEMBL10305037 0.71 BTK (0.42) HSP90AA1HSP90AB1MEN1NPC1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2009097578-A1 OXIM DERIVATIVES AS HSP90 INHIBITORS TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2009-08-06 WO disclosed