Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK8 | P49336 | 2/20 | 0.77 |
| ▸ | CDK2 | P24941 | 4/20 | 0.60 |
| ▸ | KIT | P10721 | 2/20 | 0.60 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.60 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.60 |
| ▸ | CDK9 | P50750 | 2/20 | 0.60 |
| ▸ | AXL | P30530 | 4/20 | 0.56 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.56 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.54 |
| ▸ | CDC7 | O00311 | 2/20 | 0.54 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.54 |
| ▸ | PIM1 | P11309 | 2/20 | 0.54 |
| ▸ | GSK3B | P49841 | 2/20 | 0.54 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.54 |
| ▸ | PRKACA | P17612 | 1/20 | 0.54 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.54 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.54 |
| ▸ | NTRK1 | P04629 | 4/20 | 0.54 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.52 |
| ▸ | CLK2 | P49760 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8320045 | 0.90 | CDK8 (0.73) | CDK8CDK2KITCCNT1CCNA2 | |
| SCHEMBL8313393 | 0.88 | CDK8 (0.77) | CDK8CDK2KITCCNT1CCNA2 | |
| SCHEMBL13745464 | 0.87 | CDK8 (1.00) | CDK8CDK2KITCCNT1CCNA2 | |
| SCHEMBL8320115 | 0.87 | CDK8 (0.84) | CDK8CDK2KITCCNT1CCNA2 | |
| SCHEMBL1516669 | 0.87 | CDK8 (0.76) | CDK8CDK2KITCCNT1CCNA2 | |
| SCHEMBL13745368 | 0.87 | CDK8 (0.76) | CDK8CDK2KITCCNT1CCNA2 | |
| SCHEMBL8313308 | 0.87 | CDK8 (0.76) | CDK8CDK2KITCCNT1CCNA2 | |
| SCHEMBL13745955 | 0.86 | CDK8 (0.71) | CDK8CDK2KITCCNT1CCNA2 | |
| SCHEMBL13745265 | 0.85 | CDK8 (0.70) | CDK8CDK2KITCCNT1CCNA2 | |
| SCHEMBL13745362 | 0.85 | CDK8 (0.65) | CDK8CDK2KITCCNT1CCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090215771-A1 | JNK INHIBITORS | GRACZYK PIOTR | 2009-08-27 | — | — | US | disclosed |
| US-20090215771-A1 | JNK INHIBITORS | GRACZYK PIOTR | 2009-08-27 | — | — | US | disclosed |
| US-7432375-B2 | JNK inhibitors | EISAI R & D MANAGEMENT CO., LTD. (JP) | 2008-10-07 | — | — | US | disclosed |
| US-7432375-B2 | JNK inhibitors | EISAI R & D MANAGEMENT CO., LTD. (JP) | 2008-10-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090215771-A1 | JNK INHIBITORS | MAPKAPK2, MAPK1, MAPKAPK3 | CDK8 360/4885CDK2 153/4885KIT 3148/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.