Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK8 | P49336 | 2/20 | 0.76 |
| ▸ | KIT | P10721 | 2/20 | 0.58 |
| ▸ | CDK2 | P24941 | 2/20 | 0.55 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.55 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.55 |
| ▸ | CDK9 | P50750 | 1/20 | 0.55 |
| ▸ | AXL | P30530 | 3/20 | 0.54 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.54 |
| ▸ | IGF1R | P08069 | 3/20 | 0.53 |
| ▸ | NTRK1 | P04629 | 4/20 | 0.53 |
| ▸ | JAK2 | O60674 | 1/20 | 0.52 |
| ▸ | MAP3K9 | P80192 | 1/20 | 0.51 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.51 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.50 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.49 |
| ▸ | CDC7 | O00311 | 1/20 | 0.49 |
| ▸ | PLK4 | O00444 | 1/20 | 0.49 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.49 |
| ▸ | AURKA | O14965 | 1/20 | 0.49 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13745366 | 0.87 | CDK8 (0.77) | CDK8KITCDK2CCNT1CCNA2 | |
| SCHEMBL13745361 | 0.86 | CDK8 (0.77) | CDK8KITCDK2CCNT1CCNA2 | |
| SCHEMBL13745464 | 0.86 | CDK8 (1.00) | CDK8KITCDK2CCNT1CCNA2 | |
| SCHEMBL8320115 | 0.86 | CDK8 (0.84) | CDK8KITCDK2CCNT1CCNA2 | |
| SCHEMBL8313308 | 0.86 | CDK8 (0.76) | CDK8KITCDK2CCNT1CCNA2 | |
| SCHEMBL1516669 | 0.86 | CDK8 (0.76) | CDK8KITCDK2CCNT1CCNA2 | |
| SCHEMBL13745496 | 0.84 | CDK8 (0.70) | CDK8KITCDK2CCNT1CCNA2 | |
| SCHEMBL8322704 | 0.84 | CDK8 (0.66) | CDK8KITCDK2CCNT1CCNA2 | |
| SCHEMBL8319983 | 0.84 | CDK8 (0.65) | CDK8KITCDK2CCNT1CCNA2 | |
| SCHEMBL30368403 | 0.83 | AXL (0.71) | CDK8KITCDK2CCNT1CCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090215771-A1 | JNK INHIBITORS | GRACZYK PIOTR | 2009-08-27 | — | — | US | disclosed |
| US-20090215771-A1 | JNK INHIBITORS | GRACZYK PIOTR | 2009-08-27 | — | — | US | disclosed |
| US-7432375-B2 | JNK inhibitors | EISAI R & D MANAGEMENT CO., LTD. (JP) | 2008-10-07 | — | — | US | disclosed |
| US-7432375-B2 | JNK inhibitors | EISAI R & D MANAGEMENT CO., LTD. (JP) | 2008-10-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090215771-A1 | JNK INHIBITORS | MAPKAPK2, MAPK1, MAPKAPK3 | CDK8 360/4885KIT 3148/4885CDK2 153/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.