Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HPGDS | O60760 | 1/20 | 0.43 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.42 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.41 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.41 |
| ▸ | CD38 | P28907 | 11/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.41 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.39 |
| ▸ | PI4KA | P42356 | 1/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.39 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.39 |
| ▸ | TDO2 | P48775 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4541085 | 0.78 | CD38 (0.49) | DYRK1AMAPTDYRK2DYRK1BCD38 | |
| SCHEMBL6729040 | 0.77 | DYRK1A (0.49) | DYRK1AMAPTPDE10ADYRK2DYRK1B | |
| SCHEMBL4020749 | 0.77 | PIK3CD (0.50) | DYRK1AMAPTDYRK1BCD38CHEK1 | |
| SCHEMBL18927620 | 0.77 | MAPT (0.44) | DYRK1AMAPTDYRK2DYRK1BCD38 | |
| SCHEMBL676678 | 0.77 | HPGDS (0.56) | HPGDSPDE10APIK3CDPIK3CAPIK3CB | |
| SCHEMBL13727954 | 0.75 | CD38 (0.47) | DYRK1AMAPTDYRK2DYRK1BCD38 | |
| SCHEMBL17051516 | 0.74 | HPGDS (0.54) | HPGDSPDE10APIK3CDPIK3CAPIK3CB | |
| SCHEMBL14088054 | 0.73 | CYP2C9 (0.55) | MAPTHPGDSCHEK1CHEK2NPC1 | |
| SCHEMBL18467734 | 0.72 | HPGDS (0.44) | MAPTHPGDSPDE10APIK3CDPIK3CA | |
| SCHEMBL6260 | 0.72 | DYRK1A (0.43) | DYRK1AMAPTDYRK2DYRK1BCD38 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009095377-A1 | SPIRO COMPOUNDS AS NPY Y5 RECEPTOR ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2009-08-06 | — | — | WO | disclosed |