Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 15/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.39 |
| ▸ | TNF | P01375 | 2/20 | 0.38 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.36 |
| ▸ | ATR | Q13535 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13013290 | 0.92 | TYK2 (0.49) | TYK2PDE4D | |
| SCHEMBL13062377 | 0.92 | TYK2 (0.49) | TYK2PDE4D | |
| SCHEMBL3776427 | 0.89 | TYK2 (0.45) | TYK2ATR | |
| SCHEMBL3776432 | 0.89 | TYK2 (0.45) | TYK2ATR | |
| SCHEMBL13745476 | 0.87 | TYK2 (0.40) | TYK2PDE4DATR | |
| SCHEMBL13062635 | 0.84 | TYK2 (0.45) | TYK2PDE4D | |
| SCHEMBL13062541 | 0.84 | TYK2 (0.49) | TYK2PDE4D | |
| SCHEMBL13062313 | 0.84 | TYK2 (0.45) | TYK2PDE4D | |
| SCHEMBL3767183 | 0.83 | TYK2 (0.51) | TYK2PDE4D | |
| SCHEMBL3767180 | 0.83 | TYK2 (0.51) | TYK2PDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009100375-A1 | SUBSTITUTED IMIDAZOPYRIDAZINES USEFUL AS KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-08-13 | — | — | WO | disclosed |