Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 10/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.37 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.36 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | FLT3 | P36888 | 1/20 | 0.36 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.36 |
| ▸ | ATR | Q13535 | 1/20 | 0.35 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3781925 | 0.92 | TYK2 (0.47) | TYK2NPC1RAB9AEPHX1PDE4D | |
| SCHEMBL3781922 | 0.92 | TYK2 (0.47) | TYK2NPC1RAB9AEPHX1PDE4D | |
| SCHEMBL3727050 | 0.88 | TYK2 (0.41) | TYK2PDE4DRECQLEPHX2 | |
| SCHEMBL3727051 | 0.88 | TYK2 (0.41) | TYK2PDE4DRECQLEPHX2 | |
| SCHEMBL3786962 | 0.87 | TYK2 (0.49) | TYK2EPHX1PDE4D | |
| SCHEMBL3786966 | 0.87 | TYK2 (0.49) | TYK2EPHX1PDE4D | |
| SCHEMBL3776432 | 0.87 | TYK2 (0.45) | TYK2CCNE1CDK2FLT3ATR | |
| SCHEMBL3776427 | 0.87 | TYK2 (0.45) | TYK2CCNE1CDK2FLT3ATR | |
| SCHEMBL13745427 | 0.87 | TYK2 (0.42) | TYK2PDE4DATR | |
| SCHEMBL14732026 | 0.86 | TYK2 (0.46) | TYK2NPC1RAB9AEPHX1PDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009100375-A1 | SUBSTITUTED IMIDAZOPYRIDAZINES USEFUL AS KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-08-13 | — | — | WO | disclosed |