Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 3/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | HTR6 | P50406 | 2/20 | 0.31 |
| ▸ | AURKA | O14965 | 1/20 | 0.31 |
| ▸ | MET | P08581 | 1/20 | 0.31 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.31 |
| ▸ | MTOR | P42345 | 1/20 | 0.31 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.31 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.31 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.31 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.30 |
| ▸ | MMP8 | P22894 | 2/20 | 0.30 |
| ▸ | MMP3 | P08254 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13745689 | 0.81 | PTGS2 (0.36) | BRD4ALDH1A1 | |
| SCHEMBL8321704 | 0.78 | MAPK8 (0.55) | PDPK1PIK3CDMAPK8MAPK9MAPK10 | |
| SCHEMBL13746752 | 0.77 | KIT (0.35) | PTPN11PDPK1MAPK8MAPK9MAPK10 | |
| SCHEMBL13745617 | 0.77 | CDK8 (0.38) | PTPN11ALDH1A1MAPK8MAPK9MAPK10 | |
| SCHEMBL13745553 | 0.75 | CYP2A6 (0.35) | ALDH1A1MAPTSMN1; SMN2MAPK8MAPK9 | |
| SCHEMBL13854152 | 0.74 | MC4R (0.38) | PTPN11ALDH1A1MAPK8MAPK9MAPK10 | |
| SCHEMBL8320074 | 0.73 | MAPK8 (0.37) | ALDH1A1MAPTSMN1; SMN2AURKAMAPK8 | |
| SCHEMBL1487552 | 0.73 | PTPN11 (0.47) | PTPN11BRD4PDPK1HTR6AURKA | |
| SCHEMBL13745786 | 0.72 | ABL1 (0.35) | ALDH1A1MAPTMAPK8MAPK9MAPK10 | |
| SCHEMBL13745784 | 0.71 | PTPN11 (0.45) | PTPN11BRD4PDPK1HTR6AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090215771-A1 | JNK INHIBITORS | GRACZYK PIOTR | 2009-08-27 | — | — | US | disclosed |
| US-7432375-B2 | JNK inhibitors | EISAI R & D MANAGEMENT CO., LTD. (JP) | 2008-10-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090215771-A1 | JNK INHIBITORS | MAPKAPK2, MAPK1, MAPKAPK3 | PTPN11 1694/4885BRD4 1339/4885PDPK1 279/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.