⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21267 | 1.00 | — | — | |
| SCHEMBL286696 | 0.85 | TSHR (0.48) | — | |
| SCHEMBL3884 | 0.85 | TSHR (0.48) | — | |
| SCHEMBL9421049 | 0.83 | TSHR (0.52) | — | |
| SCHEMBL62945 | 0.83 | TSHR (0.52) | — | |
| SCHEMBL2285719 | 0.81 | CES1 (0.41) | — | |
| SCHEMBL177122 | 0.81 | TSHR (0.50) | — | |
| SCHEMBL20477815 | 0.77 | TSHR (0.38) | — | |
| SCHEMBL456207 | 0.75 | TSHR (0.36) | — | |
| SCHEMBL1191865 | 0.75 | TSHR (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080269237-A1 | CARBAMIC ACID COMPOUNDS COMPRISING A PIPERAZINE LINKAGE AS HDAC INHIBITORS | TOPOTARGET UK LIMITED (GB) | 2008-10-30 | — | — | US | claimed |
| EP-1492534-B1 | CARBAMIC ACID COMPOUNDS COMPRISING A PIPERAZINE LINKAGE AS HDAC INHIBITORS | TOPOTARGET UK LTD (GB) | 2008-06-25 | — | — | EP | claimed |
| US-20050143385-A1 | Carbamic acid compounds comprising a piperazine linkage as hdac inhibitors | TOPOTARGET UK LIMITED (GB) | 2005-06-30 | — | — | US | claimed |
| EP-1492534-A1 | CARBAMIC ACID COMPOUNDS COMPRISING A PIPERAZINE LINKAGE AS HDAC INHIBITORS | TopoTarget UK Limited (GB) | 2005-01-05 | — | — | EP | claimed |
| WO-2003082288-A1 | CARBAMIC ACID COMPOUNDS COMPRISING A PIPERAZINE LINKAGE AS HDAC INHIBITORS | TOPOTARGET UK LIMITED (GB) | 2003-10-09 | — | — | WO | claimed |
| CN-108017663-B | Method for producing silane compound containing bis (silyl) amino group | 信越化学工业株式会社 | 2022-05-13 | — | — | CN | disclosed |
| US-11312734-B2 | Nitrogen-containing cyclic organoxysilane compound and method for producing the same | SHIN-ETSU CHEMICAL CO., LTD. (JP) | 2022-04-26 | — | — | US | disclosed |
| EP-3660025-A1 | NITROGEN-CONTAINING CYCLIC ORGANOXYSILANE COMPOUND AND METHOD FOR PRODUCING THE SAME | Shin-Etsu Chemical Co., Ltd. (JP) | 2020-06-03 | — | — | EP | disclosed |
| EP-3392255-B1 | UNSATURATED BOND-CONTAINING BISSILYL COMPOUND AND MAKING METHOD | SHINETSU CHEMICAL CO (JP) | 2020-06-03 | — | — | EP | disclosed |
| US-20200165276-A1 | NITROGEN-CONTAINING CYCLIC ORGANOXYSILANE COMPOUND AND METHOD FOR PRODUCING THE SAME | SHIN-ETSU CHEMICAL CO., LTD. (JP) | 2020-05-28 | — | — | US | disclosed |
| EP-3476851-A1 | POLYCYCLIC AMINOSILANE COMPOUNDS AND MAKING METHOD | Shin-Etsu Chemical Co., Ltd. (JP) | 2019-05-01 | — | — | EP | disclosed |
| US-20190119308-A1 | POLYCYCLIC AMINOSILANE COMPOUNDS AND MAKING METHOD | SHIN-ETSU CHEMICAL CO., LTD. (JP) | 2019-04-25 | — | — | US | disclosed |
| EP-1492534-B1 | CARBAMIC ACID COMPOUNDS COMPRISING A PIPERAZINE LINKAGE AS HDAC INHIBITORS | TOPOTARGET UK LTD (GB) | 2008-06-25 | — | — | EP | disclosed |
| US-20060058282-A1 | Carbamic acid compounds comprising an ester or ketone linkage as hdac inhibitors | TOPOTARGET UK LIMITED (GB) | 2006-03-16 | — | — | US | disclosed |
| EP-1583736-A1 | CARBAMIC ACID COMPOUNDS COMPRISING AN ESTER OR KETONE LINKAGE AS HDAC INHIBITORS | TopoTarget UK Limited (GB) | 2005-10-12 | — | — | EP | disclosed |
| US-20050143385-A1 | Carbamic acid compounds comprising a piperazine linkage as hdac inhibitors | TOPOTARGET UK LIMITED (GB) | 2005-06-30 | — | — | US | disclosed |
| EP-1492534-A1 | CARBAMIC ACID COMPOUNDS COMPRISING A PIPERAZINE LINKAGE AS HDAC INHIBITORS | TopoTarget UK Limited (GB) | 2005-01-05 | — | — | EP | disclosed |
| WO-2004065354-A1 | CARBAMIC ACID COMPOUNDS COMPRISING AN ESTER OR KETONE LINKAGE AS HDAC INHIBITORS | TOPOTARGET UK LIMITED (GB) | 2004-08-05 | — | — | WO | disclosed |
| WO-2003082288-A1 | CARBAMIC ACID COMPOUNDS COMPRISING A PIPERAZINE LINKAGE AS HDAC INHIBITORS | TOPOTARGET UK LIMITED (GB) | 2003-10-09 | — | — | WO | disclosed |
| EP-0131445-A2 | Polyphenylene ether resin composition | MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) | 1985-01-16 | — | — | EP | disclosed |