Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 1/20 | 0.47 |
| ▸ | MGLL | Q99685 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 6/20 | 0.43 |
| ▸ | THRA | P10827 | 5/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | PTGER2 | P43116 | 4/20 | 0.41 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.41 |
| ▸ | PTGER3 | P43115 | 3/20 | 0.41 |
| ▸ | SPHK1 | Q9NYA1 | 4/20 | 0.40 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.40 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12112012 | 1.00 | FAAH (0.47) | FAAHMGLLTHRBTHRAMEN1 | |
| SCHEMBL13693307 | 0.90 | FAAH (0.49) | FAAHMGLLPTGER2PTGER4PTGER3 | |
| SCHEMBL12568629 | 0.90 | FAAH (0.49) | FAAHMGLLPTGER2PTGER4PTGER3 | |
| SCHEMBL14444576 | 0.90 | FAAH (0.49) | FAAHMGLLPTGER2PTGER4PTGER3 | |
| SCHEMBL13125487 | 0.81 | PTGER2 (0.60) | PTGER2PTGER4PTGER3 | |
| SCHEMBL12621415 | 0.81 | FAAH (0.50) | FAAHMGLLPTGER2PTGER4PTGER3 | |
| SCHEMBL14315052 | 0.80 | PTGER2 (0.61) | PTGER2PTGER4PTGER3 | |
| SCHEMBL12568637 | 0.79 | SPHK1 (0.52) | FAAHMGLLPTGER2PTGER4PTGER3 | |
| SCHEMBL12112017 | 0.79 | SPHK1 (0.52) | FAAHMGLLPTGER2PTGER4PTGER3 | |
| SCHEMBL13780837 | 0.75 | PTGER2 (0.65) | PTGER2PTGER4PTGER3S1PR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009097223-A1 | SUBSTITUTED GAMMA LACTAMS AS THERAPEUTIC AGENTS | ALLERGAN, INC. (US) | 2009-08-06 | — | — | WO | disclosed |