Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 1/20 | 0.45 |
| ▸ | MMP2 | P08253 | 1/20 | 0.45 |
| ▸ | MMP8 | P22894 | 1/20 | 0.45 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.36 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.36 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.36 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.36 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.36 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 2/20 | 0.35 |
| ▸ | JAK1 | P23458 | 2/20 | 0.35 |
| ▸ | JAK3 | P52333 | 2/20 | 0.35 |
| ▸ | FPR3 | P25089 | 1/20 | 0.35 |
| ▸ | FPR2 | P25090 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13337051 | 0.80 | DPP4 (0.41) | MMP1MMP2MMP8JAK2JAK1 | |
| SCHEMBL24709908 | 0.79 | PREP (0.45) | MMP1MMP2MMP8JAK2JAK1 | |
| SCHEMBL8488963 | 0.78 | MMP1 (0.46) | MMP1MMP2MMP8HPGDDPP4 | |
| SCHEMBL13337035 | 0.77 | DPP4 (0.39) | MMP1MMP2MMP8JAK2JAK1 | |
| SCHEMBL13337040 | 0.77 | DPP4 (0.39) | MMP1MMP2MMP8JAK2JAK1 | |
| SCHEMBL17275494 | 0.77 | HPGD (0.41) | MMP1MMP2MMP8JAK2JAK1 | |
| SCHEMBL4239694 | 0.77 | HPGD (0.41) | MMP1MMP2MMP8JAK2JAK1 | |
| SCHEMBL17282576 | 0.77 | PREP (0.50) | MMP1MMP2MMP8JAK2JAK1 | |
| SCHEMBL8487739 | 0.77 | MMP1 (0.49) | MMP1MMP2MMP8HPGDDPP4 | |
| SCHEMBL17991731 | 0.76 | PREP (0.49) | MMP1MMP2MMP8JAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009102325-A1 | IMIDAZOLYL BIPHENYL IMIDAZOLES AS HEPATITIS C VIRUS INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-08-20 | — | — | WO | disclosed |
| WO-2008021927-A2 | HEPATITIS C VIRUS INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-02-21 | — | — | WO | disclosed |