Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 3/20 | 0.56 |
| ▸ | MAPT | P10636 | 12/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 11/20 | 0.52 |
| ▸ | MEN1 | O00255 | 4/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13748873 | 0.88 | MAPT (0.47) | KIF11MAPTKDM4EMEN1KMT2A | |
| SCHEMBL13749164 | 0.87 | MAPT (0.49) | KIF11MAPTKDM4EMEN1KMT2A | |
| SCHEMBL2783762 | 0.79 | MAPT (0.47) | KIF11MAPTKDM4EMEN1KMT2A | |
| SCHEMBL17928402 | 0.77 | ESR1 (0.69) | KIF11MAPTKDM4ELMNATP53 | |
| SCHEMBL13748468 | 0.77 | MAPT (0.48) | KIF11MAPTKDM4EMEN1KMT2A | |
| SCHEMBL13748915 | 0.76 | KDM4E (0.48) | KIF11MAPTKDM4EMEN1KMT2A | |
| SCHEMBL13912140 | 0.76 | ESR1 (0.60) | KIF11MAPTKDM4EMEN1KMT2A | |
| SCHEMBL16402752 | 0.74 | KDM4E (0.65) | KIF11MAPTKDM4EMEN1KMT2A | |
| SCHEMBL2783497 | 0.70 | KDM4E (0.48) | KIF11MAPTKDM4EMEN1KMT2A | |
| SCHEMBL13747998 | 0.70 | KDM4E (0.60) | KIF11MAPTKDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009102377-A2 | ANTIBIOTIC TETRAHYDRO-BETA-CARBOLINE DERIVATIVES | MAXTHERA INC. (US) | 2009-08-20 | — | — | WO | disclosed |