Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 11/20 | 0.48 |
| ▸ | MAPT | P10636 | 10/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 5/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | KIF11 | P52732 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | ESR1 | P03372 | 1/20 | 0.43 |
| ▸ | PGR | P06401 | 1/20 | 0.43 |
| ▸ | PDE5A | O76074 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13749166 | 0.74 | KDM4E (0.47) | KDM4EMAPTMEN1KMT2ANPSR1 | |
| SCHEMBL13748744 | 0.73 | MAPT (0.45) | KDM4EMAPTPKMMEN1KMT2A | |
| SCHEMBL13748191 | 0.73 | MAPT (0.45) | KDM4EMAPTPKMMEN1KMT2A | |
| SCHEMBL13748196 | 0.70 | KIF11 (0.56) | KDM4EMAPTPKMMEN1KMT2A | |
| SCHEMBL13749167 | 0.69 | MAPT (0.47) | KDM4EMAPTMEN1KMT2ATDP1 | |
| SCHEMBL2783762 | 0.68 | MAPT (0.47) | KDM4EMAPTMEN1KMT2AMAPK1 | |
| SCHEMBL13748873 | 0.68 | MAPT (0.47) | KDM4EMAPTPKMMEN1KMT2A | |
| SCHEMBL13749164 | 0.67 | MAPT (0.49) | KDM4EMAPTPKMMEN1KMT2A | |
| SCHEMBL23875966 | 0.65 | KIF11 (0.63) | KDM4EMAPTMEN1KMT2ANPSR1 | |
| SCHEMBL13747991 | 0.65 | MAPT (0.57) | KDM4EMAPTMEN1KMT2ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2240493-A2 | ANTIBIOTIC TETRAHYDRO-BETA-CARBOLINE DERIVATIVES | Biota Scientific Management Pty Ltd (AU) | 2010-10-20 | — | — | EP | disclosed |
| WO-2009102377-A2 | ANTIBIOTIC TETRAHYDRO-BETA-CARBOLINE DERIVATIVES | MAXTHERA INC. (US) | 2009-08-20 | — | — | WO | disclosed |