Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRCP | P42785 | 11/20 | 0.59 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.52 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.52 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.52 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.49 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13747250 | 0.92 | PRCP (0.60) | PRCPKCNH2CYP3A4CYP2C9NR1I2 | |
| SCHEMBL1745202 | 0.92 | CYP3A4 (0.60) | PRCPKCNH2CYP3A4CYP2C9NR1I2 | |
| SCHEMBL1747409 | 0.91 | PRCP (0.69) | PRCPKCNH2CYP3A4CYP2C9NR1I2 | |
| SCHEMBL10177207 | 0.91 | CYP3A4 (0.58) | PRCPKCNH2CYP3A4CYP2C9NR1I2 | |
| SCHEMBL13747515 | 0.88 | KCNH2 (0.59) | PRCPKCNH2CYP3A4CYP2C9NR1I2 | |
| SCHEMBL19578324 | 0.88 | PRCP (0.56) | PRCPKCNH2CYP3A4CYP2C9NR1I2 | |
| SCHEMBL2964380 | 0.88 | PRCP (0.58) | PRCPKCNH2CYP3A4CYP2C9NR1I2 | |
| SCHEMBL13748526 | 0.88 | KCNH2 (0.59) | PRCPKCNH2CYP3A4CYP2C9NR1I2 | |
| SCHEMBL13748645 | 0.87 | PRCP (0.68) | PRCPKCNH2CYP3A4CYP2C9NR1I2 | |
| SCHEMBL690843 | 0.87 | KCNH2 (0.62) | PRCPKCNH2CYP3A4CYP2C9NR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009102325-A1 | IMIDAZOLYL BIPHENYL IMIDAZOLES AS HEPATITIS C VIRUS INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-08-20 | — | — | WO | disclosed |
| WO-2008021927-A2 | HEPATITIS C VIRUS INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-02-21 | — | — | WO | disclosed |