Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AB1 | P08238 | 5/20 | 0.66 |
| ▸ | MAPT | P10636 | 4/20 | 0.63 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.63 |
| ▸ | HPGD | P15428 | 3/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.63 |
| ▸ | RAB9A | P51151 | 2/20 | 0.63 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.63 |
| ▸ | GAA | P10253 | 2/20 | 0.63 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.63 |
| ▸ | CBR1 | P16152 | 1/20 | 0.63 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.63 |
| ▸ | ACLY | P53396 | 1/20 | 0.63 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.63 |
| ▸ | MEN1 | O00255 | 1/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.63 |
| ▸ | F13A1 | P00488 | 1/20 | 0.59 |
| ▸ | TGM2 | P21980 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | VCP | P55072 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14212853 | 1.00 | HSP90AB1 (0.66) | HSP90AB1MAPTHSP90AA1HPGDALDH1A1 | |
| SCHEMBL19418283 | 0.88 | HSP90AB1 (0.73) | HSP90AB1MAPTHSP90AA1HPGDALDH1A1 | |
| SCHEMBL2622305 | 0.86 | HSP90AB1 (0.76) | HSP90AB1MAPTHSP90AA1HPGDALDH1A1 | |
| SCHEMBL14155841 | 0.83 | HSP90AB1 (0.72) | HSP90AB1MAPTHSP90AA1HPGDALDH1A1 | |
| SCHEMBL19418322 | 0.83 | HSP90AB1 (0.70) | HSP90AB1MAPTHSP90AA1HPGDALDH1A1 | |
| SCHEMBL10293251 | 0.83 | HSP90AB1 (0.70) | HSP90AB1MAPTHSP90AA1HPGDALDH1A1 | |
| SCHEMBL14213082 | 0.83 | F13A1 (0.85) | HSP90AB1MAPTHSP90AA1HPGDALDH1A1 | |
| SCHEMBL18966859 | 0.80 | HSP90AB1 (0.50) | HSP90AB1MAPTHSP90AA1HPGDALDH1A1 | |
| SCHEMBL14979615 | 0.80 | HSP90AB1 (0.77) | HSP90AB1MAPTHSP90AA1HPGDALDH1A1 | |
| SCHEMBL13080879 | 0.80 | HSP90AB1 (0.77) | HSP90AB1MAPTHSP90AA1HPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009105755-A2 | MACROCYCLIC PRODRUG COMPOUNDS USEFUL AS THERAPEUTICS | NEXGENIX PHARMACEUTICALS (US) | 2009-08-27 | — | — | WO | disclosed |
| WO-2009091921-A1 | SYNTHESIS OF RESORCYLIC ACID LACTONES USEFUL AS THERAPEUTIC AGENTS | UNIVERSITE DE STRASBOURG (FR) | 2009-07-23 | — | — | WO | disclosed |