SCHEMBL19418283

SCHEMBL19418283

C[C@@H]1CCCCC/C=C/C(=O)Cc2c(Cl)c(O)cc(O)c2C(=O)O1

nearest known ligand 0.73

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSP90AB1 P08238 6/20 0.73
F13A1 P00488 1/20 0.63
TGM2 P21980 1/20 0.63
HSP90AA1 P07900 4/20 0.56
MAPT P10636 4/20 0.56
ALDH1A1 P00352 4/20 0.56
HPGD P15428 3/20 0.56
GAA P10253 2/20 0.56
RAB9A P51151 2/20 0.56
NPSR1 Q6W5P4 2/20 0.56
NLRP3 Q96P20 1/20 0.56
CBR1 P16152 1/20 0.56
PTGS2 P35354 1/20 0.56
ACLY P53396 1/20 0.56
FTO Q9C0B1 1/20 0.56
MEN1 O00255 1/20 0.56
KMT2A Q03164 1/20 0.56
VCP P55072 1/20 0.51
LMNA P02545 4/20 0.48
SMN1; SMN2 Q16637 4/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14212853 0.88 HSP90AB1 (0.66) HSP90AB1F13A1TGM2HSP90AA1MAPT
SCHEMBL13748257 0.88 HSP90AB1 (0.66) HSP90AB1F13A1TGM2HSP90AA1MAPT
SCHEMBL14155841 0.86 HSP90AB1 (0.72) HSP90AB1F13A1TGM2HSP90AA1MAPT
Pochonin D SCHEMBL2683506 0.84 HSP90AB1 (1.00) HSP90AB1F13A1TGM2HSP90AA1MAPT
Pochonin D SCHEMBL10150436 0.84 HSP90AB1 (1.00) HSP90AB1F13A1TGM2HSP90AA1MAPT
Pochonin D SCHEMBL669590 0.84 HSP90AB1 (1.00) HSP90AB1F13A1TGM2HSP90AA1MAPT
Pochonin D SCHEMBL2683508 0.84 HSP90AB1 (1.00) HSP90AB1F13A1TGM2HSP90AA1MAPT
Pochonin D SCHEMBL4513578 0.84 HSP90AB1 (1.00) HSP90AB1F13A1TGM2HSP90AA1MAPT
SCHEMBL19418441 0.84 HSP90AB1 (0.72) HSP90AB1F13A1TGM2HSP90AA1MAPT
SCHEMBL19418408 0.83 HSP90AB1 (0.52) HSP90AB1F13A1TGM2HSP90AA1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2136799-B1 MACROCYCLIC COMPOUNDS USEFUL AS INHIBITORS OF KINASES AND HSP90 UNIV STRASBOURG (FR) 2017-10-04 EP disclosed