Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEK | Q02763 | 5/20 | 0.44 |
| ▸ | LCK | P06239 | 4/20 | 0.44 |
| ▸ | ABL1 | P00519 | 3/20 | 0.41 |
| ▸ | BCR | P11274 | 3/20 | 0.41 |
| ▸ | KDR | P35968 | 4/20 | 0.40 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.39 |
| ▸ | AHR | P35869 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | XBP1 | P17861 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13748796 | 0.82 | LCK (0.65) | TEKLCKABL1BCRKDR | |
| SCHEMBL13748620 | 0.79 | MAPT (0.48) | KDRGAAMAPTNPSR1ALDH1A1 | |
| SCHEMBL4041879 | 0.70 | LCK (0.71) | TEKLCKABL1BCRKDR | |
| SCHEMBL4038933 | 0.70 | LCK (0.71) | TEKLCKABL1BCRKDR | |
| SCHEMBL4039305 | 0.66 | MAPT (0.57) | KDRGAAMAPTNPSR1ALDH1A1 | |
| SCHEMBL4035224 | 0.66 | MAPT (0.57) | KDRGAAMAPTNPSR1ALDH1A1 | |
| SCHEMBL4715351 | 0.65 | LCK (0.78) | TEKLCKKDRMAPTALDH1A1 | |
| SCHEMBL22103806 | 0.63 | KMT2A (0.64) | TEKLCKKDRMAPTALDH1A1 | |
| SCHEMBL14106173 | 0.62 | HTT (0.63) | ALDH1A1PTPN1RXFP1MEN1KMT2A | |
| SCHEMBL4720436 | 0.62 | TEK (0.61) | TEKLCKABL1BCRKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009100536-A1 | INHIBITORS OF KINASE ACTIVITY WITH 1,2-DI-CYCLYL SUBSTITUTED ALKYNE STRUCTURES | METHYLGENE INC. (CA) | 2009-08-20 | — | — | WO | disclosed |