Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | HTT | P42858 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | KDR | P35968 | 1/20 | 0.52 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | CA12 | O43570 | 1/20 | 0.49 |
| ▸ | CA1 | P00915 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
| ▸ | CA9 | Q16790 | 1/20 | 0.49 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4039305 | 1.00 | MAPT (0.57) | MAPTKMT2AHTTMEN1RAB9A | |
| SCHEMBL4037834 | 0.91 | KMT2A (0.68) | MAPTKMT2AHTTMEN1RAB9A | |
| SCHEMBL30080659 | 0.91 | KMT2A (0.68) | MAPTKMT2AHTTMEN1RAB9A | |
| SCHEMBL13748620 | 0.85 | MAPT (0.48) | MAPTKMT2AHTTMEN1RAB9A | |
| SCHEMBL4037469 | 0.83 | RAB9A (0.50) | MAPTKMT2AMEN1RAB9ALMNA | |
| SCHEMBL26343455 | 0.82 | SMARCA2 (0.52) | MAPTKMT2AMEN1RAB9AALDH1A1 | |
| SCHEMBL4219457 | 0.82 | MAPT (0.71) | MAPTKMT2AHTTMEN1RAB9A | |
| SCHEMBL5444452 | 0.82 | BAZ1A (0.66) | MAPTKMT2AHTTMEN1RAB9A | |
| SCHEMBL4041879 | 0.80 | LCK (0.71) | MAPTKMT2AHTTMEN1RAB9A | |
| SCHEMBL4038933 | 0.80 | LCK (0.71) | MAPTKMT2AHTTMEN1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009100536-A1 | INHIBITORS OF KINASE ACTIVITY WITH 1,2-DI-CYCLYL SUBSTITUTED ALKYNE STRUCTURES | METHYLGENE INC. (CA) | 2009-08-20 | — | — | WO | disclosed |