Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | LSS | P48449 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL394065 | 0.83 | TP53 (0.42) | HTTTP53ALDH1A1KDM4ECYP3A4 | |
| SCHEMBL28360711 | 0.82 | HTT (0.44) | HTTTP53ALDH1A1KDM4ELMNA | |
| SCHEMBL5485827 | 0.78 | ALDH1A1 (0.45) | HTTTP53ALDH1A1CYP3A4MAPT | |
| SCHEMBL5201293 | 0.77 | KMT2A (0.48) | ALDH1A1LMNAMAPTPOLBKMT2A | |
| SCHEMBL2308001 | 0.74 | ALDH1A1 (0.45) | HTTTP53ALDH1A1LMNAMAPT | |
| SCHEMBL13651184 | 0.74 | ALDH1A1 (0.40) | HTTTP53ALDH1A1CYP3A4MAPT | |
| SCHEMBL5461493 | 0.73 | TP53 (0.45) | HTTTP53ALDH1A1KDM4ECYP3A4 | |
| SCHEMBL3162449 | 0.70 | ALDH1A1 (0.48) | HTTTP53ALDH1A1KDM4ECYP2C9 | |
| SCHEMBL6223340 | 0.70 | ALDH1A1 (0.40) | HTTTP53ALDH1A1KDM4ELMNA | |
| SCHEMBL11484797 | 0.69 | ALDH1A1 (0.33) | HTTTP53ALDH1A1KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7579347-B2 | Vanilloid receptor ligands and their use in treatments | AMGEN INC. (US) | 2009-08-25 | — | — | US | disclosed |